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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rnaseltm1Slvm
targeted mutation 1, Robert H Silverman
MGI:2182763
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rnaseltm1Slvm/Rnaseltm1Slvm involves: 129P2/OlaHsd MGI:3039027
cx2
 		Eif2ak2tm1Cwe/Eif2ak2tm1Cwe
Rnaseltm1Slvm/Rnaseltm1Slvm 		involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 MGI:3039029
cx3
 		Adarem1Stsn/Adartm1Olds
Rnaseltm1Slvm/Rnaseltm1Slvm 		involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J MGI:7281851


Genotype
MGI:3039027
hm1
Allelic
Composition		 Rnaseltm1Slvm/Rnaseltm1Slvm
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rnaseltm1Slvm mutation (0 available); any Rnasel mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased T cell apoptosis ( J:44292 )
• decreased apoptosis in T-cells of the spleen and thymus
• isolated thymocytes also resistant to induction of apoptosis
thymus hyperplasia ( J:44292 )
• 1.6X increase in the number of thymocytes in the cortex region of the thymus
increased susceptibility to Picornaviridae infection ( J:44292 )
• susceptibility to encephalomyocarditis virus tested
• suppressed antiviral effect of interferon

hematopoietic system
decreased T cell apoptosis ( J:44292 )
• decreased apoptosis in T-cells of the spleen and thymus
• isolated thymocytes also resistant to induction of apoptosis
thymus hyperplasia ( J:44292 )
• 1.6X increase in the number of thymocytes in the cortex region of the thymus

cellular
decreased T cell apoptosis ( J:44292 )
• decreased apoptosis in T-cells of the spleen and thymus
• isolated thymocytes also resistant to induction of apoptosis

endocrine/exocrine glands
thymus hyperplasia ( J:44292 )
• 1.6X increase in the number of thymocytes in the cortex region of the thymus




Genotype
MGI:3039029
cx2
Allelic
Composition		 Eif2ak2tm1Cwe/Eif2ak2tm1Cwe
Rnaseltm1Slvm/Rnaseltm1Slvm
Genetic
Background		 involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eif2ak2tm1Cwe mutation (2 available); any Eif2ak2 mutation (41 available)
Rnaseltm1Slvm mutation (0 available); any Rnasel mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased susceptibility to Picornaviridae infection ( J:55974 )
• susceptibility to encephalomyocarditis virus tested
• antiviral effect of interferon was suppressed even more than in the case of either single homozygote




Genotype
MGI:7281851
cx3
Allelic
Composition		 Adarem1Stsn/Adartm1Olds
Rnaseltm1Slvm/Rnaseltm1Slvm
Genetic
Background		 involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adarem1Stsn mutation (0 available); any Adar mutation (72 available)
Adartm1Olds mutation (0 available); any Adar mutation (72 available)
Rnaseltm1Slvm mutation (0 available); any Rnasel mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
growth/size/body region phenotype ( J:308678 )
• normal weight, weight gain and growth

mortality/aging
mortality/aging ( J:308678 )
N
• normal survival




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory