Phenotypes associated with this allele

• Allele Symbol: Mzf1^tm1Ppp
• Allele Name: targeted mutation 1, Pier Paolo Pandolfi
• Allele ID: MGI:2182764
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mzf1^tm1Ppp/Mzf1^tm1Ppp	involves: 129	MGI:2653380

Genotype
MGI:2653380

hm1

• Allelic Composition: Mzf1^tm1Ppp/Mzf1^tm1Ppp
• Genetic Background: involves: 129

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:70407 )

• 30% developed neoplastic disease affecting liver and spleen and to which they succumbed between 24 and 32 months of age

neoplasm

increased hepatocellular carcinoma incidence ( J:70407 )

• 30% of mice developed neoplastic disease affecting liver and spleen between 24 and 32 months of age

increased spleen neoplasm incidence ( J:70407 )

• 30% developed neoplastic disease affecting liver and spleen and to which they succumbed between 24 and 32 months of age

hematopoietic system

hematopoietic system phenotype ( J:70407 )

N • while bone marrow and spleen showed cellular abnormalities, the lymphoid compartment showed normal differential counts and normal stem cell, myeloid cell, and T- and B-lymphocyte numbers

N • peripheral blood cell differential counts were normal

abnormal myelopoiesis ( J:70407 )

• progressive and consistent accumulation of mature Mac-1+ myeloid population in the bone marrow

extramedullary hematopoiesis ( J:70407 )

• evident in all mice over the age of 2 years

immune system

abnormal myelopoiesis ( J:70407 )

• progressive and consistent accumulation of mature Mac-1+ myeloid population in the bone marrow

abnormal bone marrow development ( J:70407 )

• progressive and consistent accumulation of mature Mac-1+ myeloid population in the bone marrow

liver/biliary system

increased hepatocellular carcinoma incidence ( J:70407 )

• 30% of mice developed neoplastic disease affecting liver and spleen between 24 and 32 months of age