All Phenotypes Elane<tm1Sds> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Elane^tm1Sds
targeted mutation 1, Steven D Shapiro
MGI:2182771

Summary

8 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Elane^tm1Sds/Elane^tm1Sds	129X1/SvJ-Elane^tm1Sds	MGI:3785260
hm2	Elane^tm1Sds/Elane^tm1Sds	B6.129X1-Elane^tm1Sds	MGI:3785368
hm3	Elane^tm1Sds/Elane^tm1Sds	B6.129X1-Elane^tm1Sds/J	MGI:6380700
hm4	Elane^tm1Sds/Elane^tm1Sds	involves: 129X1/SvJ	MGI:3785262
hm5	Elane^tm1Sds/Elane^tm1Sds	involves: 129X1/SvJ * C57BL/6	MGI:3785284
cx6	Ctsg^tm1Ley/Ctsg^tm1Ley Elane^tm1Sds/Elane^tm1Sds	B6.129X1-Elane^tm1Sds Ctsg^tm1Ley	MGI:3785270
cx7	Ctsg^{tm2.1(PML/RARA)Ley}/Ctsg⁺ Elane^tm1Sds/Elane^tm1Sds	involves: 129S/SvEv * 129X1/SvJ * C57BL/6	MGI:3526663
cx8	Ctsg^tm1Ley/Ctsg^tm1Ley Elane^tm1Sds/Elane^tm1Sds	involves: 129X1/SvJ	MGI:3785269

Allelic Composition	Elane^tm1Sds/Elane^tm1Sds
Genetic Background	129X1/SvJ-Elane^tm1Sds

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Elane^tm1Sds mutation (2 available); any Elane mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased susceptibility to bacterial infection induced morbidity/mortality ( J:47420 )

• mice are less susceptible to death induced by Gram positive Staphylococcus aureus infection compared to wild-type mice

increased susceptibility to bacterial infection induced morbidity/mortality ( J:47420 )

• at 16 hours following infection with Gram negative Klebsiella pneumoniae, 50% of mice are dead unlike wild-type mice that do not display mortality due to infection at 16 hours

• at 48 hours following infection with Klebsiella pneumoniae, all mice are dead unlike wild-type mice that display 50% mortality

immune system

abnormal neutrophil physiology ( J:47420 )

• despite normal neutrophil recruitment, recognition and binding, neutrophils fail to degrade phagocytosed Klebsiella pneumoniae or Escherichia coli unlike in wild-type mice

decreased susceptibility to bacterial infection induced morbidity/mortality ( J:47420 )

• mice are less susceptible to death induced by Gram positive Staphylococcus aureus infection compared to wild-type mice

increased susceptibility to bacterial infection ( J:47420 )

• mice appear clinically worse than wild-type mice following infection with Gram negative Klebsiella pneumoniae or Escherichia coli

• when infected with Klebsiella pneumoniae, mice exhibit signs of severe infection including ruffled fur, hunched posture, impaired ambulation and diarrhea unlike wild-type mice

• despite normal neutrophil recruitment, recognition and binding, bacterial burden is greater than in wild-type mice following infection with Klebsiella pneumoniae

increased susceptibility to bacterial infection induced morbidity/mortality ( J:47420 )

• at 16 hours following infection with Gram negative Klebsiella pneumoniae, 50% of mice are dead unlike wild-type mice that do not display mortality due to infection at 16 hours

• at 48 hours following infection with Klebsiella pneumoniae, all mice are dead unlike wild-type mice that display 50% mortality

hematopoietic system

abnormal neutrophil physiology ( J:47420 )

• despite normal neutrophil recruitment, recognition and binding, neutrophils fail to degrade phagocytosed Klebsiella pneumoniae or Escherichia coli unlike in wild-type mice

Allelic Composition	Elane^tm1Sds/Elane^tm1Sds
Genetic Background	B6.129X1-Elane^tm1Sds

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Elane^tm1Sds mutation (2 available); any Elane mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased physiological sensitivity to xenobiotic ( J:86599 )

• mice exhibit 59% protection from emphysema induced by a 6 month cigarette smoke exposure

• following a 6 month exposure to cigarette smoke, mice exhibit fewer neutrophils and 60% less macrophages in bronchoalveolar lavage samples compared to wild-type mice

Allelic Composition	Elane^tm1Sds/Elane^tm1Sds
Genetic Background	B6.129X1-Elane^tm1Sds/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Elane^tm1Sds mutation (2 available); any Elane mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal pain threshold ( J:220590 )

• mechanical allodynia is reduced up to 21 days after spared nerve injury

homeostasis/metabolism

abnormal response to injury ( J:220590 )

• mechanical allodynia is reduced up to 21 days after spared nerve injury

• recombination activating gene 2-null mice adoptively transferred with mutant T-cells do not develop mechanical hypersensitivity after spared nerve injury compared to transfer of wild-type cells which restores mechanical allodynia

Allelic Composition	Elane^tm1Sds/Elane^tm1Sds
Genetic Background	involves: 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Elane^tm1Sds mutation (2 available); any Elane mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased physiological sensitivity to xenobiotic ( J:124377 )

• unlike in wild-type mice, ONO-5046 has no inhibitory effects on IL-1beta-induced leukocyte transmigration

Allelic Composition	Elane^tm1Sds/Elane^tm1Sds
Genetic Background	involves: 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Elane^tm1Sds mutation (2 available); any Elane mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal inflammatory response ( J:113463 )

• following exposure to LPS then challenge with TNF at the same site to initiate a local Shwartman response, mice fail to exhibit hemorrhage or fibrin deposition, characteristic of thrombohemorrhagic vasculitis, unlike in wild-type mice despite normal neutrophil accumulation

Allelic Composition	Ctsg^tm1Ley/Ctsg^tm1Ley Elane^tm1Sds/Elane^tm1Sds
Genetic Background	B6.129X1-Elane^tm1Sds Ctsg^tm1Ley

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctsg^tm1Ley mutation (0 available); any Ctsg mutation (13 available)
Elane^tm1Sds mutation (2 available); any Elane mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:131520 )

N	• mice exhibit a normal response to infection with Sendai virus

Allelic Composition	Ctsg^{tm2.1(PML/RARA)Ley}/Ctsg⁺ Elane^tm1Sds/Elane^tm1Sds
Genetic Background	involves: 129S/SvEv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctsg^{tm2.1(PML/RARA)Ley} mutation (0 available); any Ctsg mutation (13 available)
Elane^tm1Sds mutation (2 available); any Elane mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased leukemia incidence ( J:86458 )

• heterozygotes develop acute promyelocytic leukemia with only 45% penetrance by 350 days of age, despite the decreased incidence of leukemia the phenotype of the leukemias was the same as in Ctsg^tm2.1Ley heterozygotes

hematopoietic system

abnormal myelopoiesis ( J:86458 )

• splenic myeloid expansion and aberrant CD34 Gr-1 double positive cells are seen in all mutants

immune system

abnormal myelopoiesis ( J:86458 )

• splenic myeloid expansion and aberrant CD34 Gr-1 double positive cells are seen in all mutants

Allelic Composition	Ctsg^tm1Ley/Ctsg^tm1Ley Elane^tm1Sds/Elane^tm1Sds
Genetic Background	involves: 129X1/SvJ

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:131496 )

N	• mice exhibit normal granulopoiesis

immune system

immune system phenotype ( J:131496 )

N	• mice exhibit normal granulopoiesis

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 10/29/2024 MGI 6.24