All Phenotypes Elane<tm1Sds> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Elane^tm1Sds
targeted mutation 1, Steven D Shapiro
MGI:2182771

Summary

8 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Elane^tm1Sds/Elane^tm1Sds	129X1/SvJ-Elane^tm1Sds	MGI:3785260
hm2	Elane^tm1Sds/Elane^tm1Sds	B6.129X1-Elane^tm1Sds	MGI:3785368
hm3	Elane^tm1Sds/Elane^tm1Sds	B6.129X1-Elane^tm1Sds/J	MGI:6380700
hm4	Elane^tm1Sds/Elane^tm1Sds	involves: 129X1/SvJ	MGI:3785262
hm5	Elane^tm1Sds/Elane^tm1Sds	involves: 129X1/SvJ * C57BL/6	MGI:3785284
cx6	Ctsg^tm1Ley/Ctsg^tm1Ley Elane^tm1Sds/Elane^tm1Sds	B6.129X1-Elane^tm1Sds Ctsg^tm1Ley	MGI:3785270
cx7	Ctsg^{tm2.1(PML/RARA)Ley}/Ctsg⁺ Elane^tm1Sds/Elane^tm1Sds	involves: 129S/SvEv * 129X1/SvJ * C57BL/6	MGI:3526663
cx8	Ctsg^tm1Ley/Ctsg^tm1Ley Elane^tm1Sds/Elane^tm1Sds	involves: 129X1/SvJ	MGI:3785269

Allelic Composition	Elane^tm1Sds/Elane^tm1Sds
Genetic Background	129X1/SvJ-Elane^tm1Sds

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Elane^tm1Sds mutation (2 available); any Elane mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased susceptibility to bacterial infection induced morbidity/mortality ( J:47420 )

• mice are less susceptible to death induced by Gram positive Staphylococcus aureus infection compared to wild-type mice

increased susceptibility to bacterial infection induced morbidity/mortality ( J:47420 )

• at 16 hours following infection with Gram negative Klebsiella pneumoniae, 50% of mice are dead unlike wild-type mice that do not display mortality due to infection at 16 hours

• at 48 hours following infection with Klebsiella pneumoniae, all mice are dead unlike wild-type mice that display 50% mortality

immune system

abnormal neutrophil physiology ( J:47420 )

• despite normal neutrophil recruitment, recognition and binding, neutrophils fail to degrade phagocytosed Klebsiella pneumoniae or Escherichia coli unlike in wild-type mice

decreased susceptibility to bacterial infection induced morbidity/mortality ( J:47420 )

• mice are less susceptible to death induced by Gram positive Staphylococcus aureus infection compared to wild-type mice

increased susceptibility to bacterial infection ( J:47420 )

• mice appear clinically worse than wild-type mice following infection with Gram negative Klebsiella pneumoniae or Escherichia coli

• when infected with Klebsiella pneumoniae, mice exhibit signs of severe infection including ruffled fur, hunched posture, impaired ambulation and diarrhea unlike wild-type mice

• despite normal neutrophil recruitment, recognition and binding, bacterial burden is greater than in wild-type mice following infection with Klebsiella pneumoniae

increased susceptibility to bacterial infection induced morbidity/mortality ( J:47420 )

• at 16 hours following infection with Gram negative Klebsiella pneumoniae, 50% of mice are dead unlike wild-type mice that do not display mortality due to infection at 16 hours

• at 48 hours following infection with Klebsiella pneumoniae, all mice are dead unlike wild-type mice that display 50% mortality

hematopoietic system

abnormal neutrophil physiology ( J:47420 )

• despite normal neutrophil recruitment, recognition and binding, neutrophils fail to degrade phagocytosed Klebsiella pneumoniae or Escherichia coli unlike in wild-type mice

Allelic Composition	Elane^tm1Sds/Elane^tm1Sds
Genetic Background	B6.129X1-Elane^tm1Sds

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Elane^tm1Sds mutation (2 available); any Elane mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased physiological sensitivity to xenobiotic ( J:86599 )

• mice exhibit 59% protection from emphysema induced by a 6 month cigarette smoke exposure

• following a 6 month exposure to cigarette smoke, mice exhibit fewer neutrophils and 60% less macrophages in bronchoalveolar lavage samples compared to wild-type mice

Allelic Composition	Elane^tm1Sds/Elane^tm1Sds
Genetic Background	B6.129X1-Elane^tm1Sds/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Elane^tm1Sds mutation (2 available); any Elane mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal pain threshold ( J:220590 )

• mechanical allodynia is reduced up to 21 days after spared nerve injury

homeostasis/metabolism

abnormal response to injury ( J:220590 )

• mechanical allodynia is reduced up to 21 days after spared nerve injury

• recombination activating gene 2-null mice adoptively transferred with mutant T-cells do not develop mechanical hypersensitivity after spared nerve injury compared to transfer of wild-type cells which restores mechanical allodynia

Allelic Composition	Elane^tm1Sds/Elane^tm1Sds
Genetic Background	involves: 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Elane^tm1Sds mutation (2 available); any Elane mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased physiological sensitivity to xenobiotic ( J:124377 )

• unlike in wild-type mice, ONO-5046 has no inhibitory effects on IL-1beta-induced leukocyte transmigration

Allelic Composition	Elane^tm1Sds/Elane^tm1Sds
Genetic Background	involves: 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Elane^tm1Sds mutation (2 available); any Elane mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal inflammatory response ( J:113463 )

• following exposure to LPS then challenge with TNF at the same site to initiate a local Shwartman response, mice fail to exhibit hemorrhage or fibrin deposition, characteristic of thrombohemorrhagic vasculitis, unlike in wild-type mice despite normal neutrophil accumulation

Allelic Composition	Ctsg^tm1Ley/Ctsg^tm1Ley Elane^tm1Sds/Elane^tm1Sds
Genetic Background	B6.129X1-Elane^tm1Sds Ctsg^tm1Ley

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctsg^tm1Ley mutation (0 available); any Ctsg mutation (13 available)
Elane^tm1Sds mutation (2 available); any Elane mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:131520 )

N	• mice exhibit a normal response to infection with Sendai virus

Allelic Composition	Ctsg^{tm2.1(PML/RARA)Ley}/Ctsg⁺ Elane^tm1Sds/Elane^tm1Sds
Genetic Background	involves: 129S/SvEv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctsg^{tm2.1(PML/RARA)Ley} mutation (0 available); any Ctsg mutation (13 available)
Elane^tm1Sds mutation (2 available); any Elane mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased leukemia incidence ( J:86458 )

• heterozygotes develop acute promyelocytic leukemia with only 45% penetrance by 350 days of age, despite the decreased incidence of leukemia the phenotype of the leukemias was the same as in Ctsg^tm2.1Ley heterozygotes

hematopoietic system

abnormal myelopoiesis ( J:86458 )

• splenic myeloid expansion and aberrant CD34 Gr-1 double positive cells are seen in all mutants

immune system

abnormal myelopoiesis ( J:86458 )

• splenic myeloid expansion and aberrant CD34 Gr-1 double positive cells are seen in all mutants

Allelic Composition	Ctsg^tm1Ley/Ctsg^tm1Ley Elane^tm1Sds/Elane^tm1Sds
Genetic Background	involves: 129X1/SvJ

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:131496 )

N	• mice exhibit normal granulopoiesis

immune system

immune system phenotype ( J:131496 )

N	• mice exhibit normal granulopoiesis

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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