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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		H1f0tm1Ais
targeted mutation 1, Art I Skoultchi
MGI:2182779
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		H1f0tm1Ais/H1f0tm1Ais involves: 129P2/OlaHsd * C57BL/6 MGI:3844493
cx2
 		H1f0tm1Ais/H1f0tm1Ais
H1f2tm2Ais/H1f2tm2Ais
H1f3tm2Ais/H1f3tm2Ais
H1f4tm2Ais/H1f4tm2Ais 		involves: 129/Sv * C57BL/6 * SJL MGI:2674074
cx3
 		H1f0tm1Ais/H1f0tm1Ais
H1f2tm2Ais/H1f2tm2Ais
H1f4tm2Ais/H1f4tm2Ais 		involves: 129/Sv * C57BL/6 * SJL MGI:2674076
cx4
 		H1f0tm1Ais/H1f0tm1Ais
H1f2tm1Ais/H1f2tm1Ais 		involves: 129P2/OlaHsd * C57BL MGI:3844478
cx5
 		H1f0tm1Ais/H1f0tm1Ais
H1f4tm1Ais/H1f4tm1Ais 		involves: 129P2/OlaHsd * C57BL/6 MGI:3844467
cx6
 		H1f0tm1Ais/H1f0tm1Ais
H1f3tm1Ais/H1f3tm1Ais 		involves: 129P2/OlaHsd * C57BL/6 MGI:3844473


Genotype
MGI:3844493
hm1
Allelic
Composition		 H1f0tm1Ais/H1f0tm1Ais
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H1f0tm1Ais mutation (0 available); any H1f0 mutation (13 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:26848 )
• viable, fertile and overtly normal
• no apparent anatomic or histologic abnormalities
• no defects in cell division patterns




Genotype
MGI:2674074
cx2
Allelic
Composition		 H1f0tm1Ais/H1f0tm1Ais
H1f2tm2Ais/H1f2tm2Ais
H1f3tm2Ais/H1f3tm2Ais
H1f4tm2Ais/H1f4tm2Ais
Genetic
Background		 involves: 129/Sv * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H1f0tm1Ais mutation (0 available); any H1f0 mutation (13 available)
H1f2tm2Ais mutation (0 available); any H1f2 mutation (16 available)
H1f3tm2Ais mutation (0 available); any H1f3 mutation (8 available)
H1f4tm2Ais mutation (0 available); any H1f4 mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, complete penetrance ( J:83954 )
• no homozygotes are born

embryo
abnormal embryonic tissue morphology ( J:83954 )
• E9.5 embryos are severely retarded and abnormal




Genotype
MGI:2674076
cx3
Allelic
Composition		 H1f0tm1Ais/H1f0tm1Ais
H1f2tm2Ais/H1f2tm2Ais
H1f4tm2Ais/H1f4tm2Ais
Genetic
Background		 involves: 129/Sv * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H1f0tm1Ais mutation (0 available); any H1f0 mutation (13 available)
H1f2tm2Ais mutation (0 available); any H1f2 mutation (16 available)
H1f4tm2Ais mutation (0 available); any H1f4 mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, incomplete penetrance ( J:83954 )
• homozygotes are under represented in litters at birth

growth/size/body
decreased body size ( J:83954 )
• mice are much smaller at birth and as adults

immune system
small thymus ( J:83954 )
• histologically normal however

reproductive system
reduced fertility ( J:83954 )
• both male and female mutants are fertile when crossed to wild-type mice but display reduced fertility when crossed to one another

hematopoietic system
small thymus ( J:83954 )
• histologically normal however

endocrine/exocrine glands
small thymus ( J:83954 )
• histologically normal however




Genotype
MGI:3844478
cx4
Allelic
Composition		 H1f0tm1Ais/H1f0tm1Ais
H1f2tm1Ais/H1f2tm1Ais
Genetic
Background		 involves: 129P2/OlaHsd * C57BL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H1f0tm1Ais mutation (0 available); any H1f0 mutation (13 available)
H1f2tm1Ais mutation (0 available); any H1f2 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype




Genotype
MGI:3844467
cx5
Allelic
Composition		 H1f0tm1Ais/H1f0tm1Ais
H1f4tm1Ais/H1f4tm1Ais
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H1f0tm1Ais mutation (0 available); any H1f0 mutation (13 available)
H1f4tm1Ais mutation (0 available); any H1f4 mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype




Genotype
MGI:3844473
cx6
Allelic
Composition		 H1f0tm1Ais/H1f0tm1Ais
H1f3tm1Ais/H1f3tm1Ais
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H1f0tm1Ais mutation (0 available); any H1f0 mutation (13 available)
H1f3tm1Ais mutation (0 available); any H1f3 mutation (8 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory