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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ets1tm1Jml
targeted mutation 1, Jeffrey M Leiden
MGI:2182789
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ets1tm1Jml/Ets1tm1Jml involves: 129S/SvEv * C57BL/6 MGI:3833458
cn2
 		Ets1tm1Jml/Ets1tm1Jml
Ets2tm5.1Rgo/Ets2tm5.1Rgo
Meox2tm1(cre)Sor/Meox2+ 		involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 * FVB/N MGI:4353414
cn3
 		Ets1tm1Jml/Ets1tm1Jml
Ets2tm5.1Rgo/Ets2tm5.1Rgo
Tg(Tek-cre)1Ywa/0 		involves: 129S/SvEv * C57BL/6 * FVB/N MGI:4353416
cx4
 		Ets1tm1Jml/Ets1tm1Jml
Tg(TcraH-Y,TcrbH-Y)71Vbo/0 		involves: 129S/SvEv * C57BL/6 * C57BL/6J * DBA/2J MGI:3833459
cx5
 		Ets1tm1Jml/Ets1tm1Jml
Ets2tm2Rgo/Ets2tm2Rgo 		involves: 129S/SvEv * C57BL/6 * FVB/N MGI:4353402


Genotype
MGI:3833458
hm1
Allelic
Composition		 Ets1tm1Jml/Ets1tm1Jml
Genetic
Background		 involves: 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ets1tm1Jml mutation (0 available); any Ets1 mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal CD8-positive, alpha-beta T cell differentiation ( J:125056 )
• the development of single positive T cells in the thymus is skewed away from CD8+ T cells compared to in wild-type mice
• however, no skewing was observed in peripheral tissues indicating adequate seeding of peripheral tissues or homeostatic expansion
• defective D8+ T cell differentiation is thymocyte intrinsic as determined by transplant assays
increased double-negative T cell number ( J:125056 )
• without a change in NK1.1 expression
decreased CD4-positive, alpha-beta T cell number ( J:125056 )
• the number of single positive CD4+ T cells is decreased in lymph nodes and slightly decreased in the spleen compared to in wild-type mice
decreased CD8-positive, alpha-beta T cell number ( J:125056 )
• the number of single positive CD8+ T cells is decreased in the thymus and lymph nodes and slightly decreased in the spleen compared to in wild-type mice

hematopoietic system
abnormal CD8-positive, alpha-beta T cell differentiation ( J:125056 )
• the development of single positive T cells in the thymus is skewed away from CD8+ T cells compared to in wild-type mice
• however, no skewing was observed in peripheral tissues indicating adequate seeding of peripheral tissues or homeostatic expansion
• defective D8+ T cell differentiation is thymocyte intrinsic as determined by transplant assays
increased double-negative T cell number ( J:125056 )
• without a change in NK1.1 expression
decreased CD4-positive, alpha-beta T cell number ( J:125056 )
• the number of single positive CD4+ T cells is decreased in lymph nodes and slightly decreased in the spleen compared to in wild-type mice
decreased CD8-positive, alpha-beta T cell number ( J:125056 )
• the number of single positive CD8+ T cells is decreased in the thymus and lymph nodes and slightly decreased in the spleen compared to in wild-type mice

endocrine/exocrine glands




Genotype
MGI:4353414
cn2
Allelic
Composition		 Ets1tm1Jml/Ets1tm1Jml
Ets2tm5.1Rgo/Ets2tm5.1Rgo
Meox2tm1(cre)Sor/Meox2+
Genetic
Background		 involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ets1tm1Jml mutation (0 available); any Ets1 mutation (28 available)
Ets2tm5.1Rgo mutation (0 available); any Ets2 mutation (39 available)
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, complete penetrance ( J:151187 )
• die between E11.5 and E15.5

cardiovascular system
hemorrhage ( J:151187 )
• seen at E11.5 in some embryos

homeostasis/metabolism
edema ( J:151187 )
• seen at E11.5 in some embryos




Genotype
MGI:4353416
cn3
Allelic
Composition		 Ets1tm1Jml/Ets1tm1Jml
Ets2tm5.1Rgo/Ets2tm5.1Rgo
Tg(Tek-cre)1Ywa/0
Genetic
Background		 involves: 129S/SvEv * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ets1tm1Jml mutation (0 available); any Ets1 mutation (28 available)
Ets2tm5.1Rgo mutation (0 available); any Ets2 mutation (39 available)
Tg(Tek-cre)1Ywa mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

cellular
increased vascular endothelial cell apoptosis ( J:151187 )
• increase in endothelial cell apoptosis at E11.5 and E13.5

cardiovascular system
abnormal vascular branching morphogenesis ( J:151187 )
• defect in branching seen at E10.5 and E11.5
• increase in inter blood vessel spacing
increased vascular endothelial cell apoptosis ( J:151187 )
• increase in endothelial cell apoptosis at E11.5 and E13.5




Genotype
MGI:3833459
cx4
Allelic
Composition		 Ets1tm1Jml/Ets1tm1Jml
Tg(TcraH-Y,TcrbH-Y)71Vbo/0
Genetic
Background		 involves: 129S/SvEv * C57BL/6 * C57BL/6J * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ets1tm1Jml mutation (0 available); any Ets1 mutation (28 available)
Tg(TcraH-Y,TcrbH-Y)71Vbo mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:125056 )
N
• CD4+ cells do not express HY TCR

hematopoietic system




Genotype
MGI:4353402
cx5
Allelic
Composition		 Ets1tm1Jml/Ets1tm1Jml
Ets2tm2Rgo/Ets2tm2Rgo
Genetic
Background		 involves: 129S/SvEv * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ets1tm1Jml mutation (0 available); any Ets1 mutation (28 available)
Ets2tm2Rgo mutation (0 available); any Ets2 mutation (39 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
lethality throughout fetal growth and development, complete penetrance ( J:151187 )
• fewer than expected embryos are seen at E11.5 with all lost before E15.5
embryonic lethality during organogenesis, incomplete penetrance ( J:151187 )
• fewer than expected embryos are seen at E11.5 with all lost before E15.5

cellular
increased vascular endothelial cell apoptosis ( J:151187 )
• increase in endothelial cell apoptosis at E11.5 and E13.5

cardiovascular system
abnormal vascular branching morphogenesis ( J:151187 )
• striking decrease in vascular complexity at E10.5
• defect in branching is also seen at E9.5 and E11.5
• increase in inter blood vessel spacing
dilated vasculature ( J:151187 )
• dilation is often seen at E10.5 with the distinction between large and small vessels unclear
• at E11.5, some embryos have large visibly dilated blood vessels
hemorrhage ( J:151187 )
• seen at E11.5 in some embryos
increased vascular endothelial cell apoptosis ( J:151187 )
• increase in endothelial cell apoptosis at E11.5 and E13.5

homeostasis/metabolism
edema ( J:151187 )
• seen at E11.5 in some embryos

embryo
embryo phenotype ( J:151187 )
N
• in embryos without visible vascular abnormalities, no defects are detected in the placental labyrinth layer




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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory