Phenotypes associated with this allele

• Allele Symbol: Camp^tm1Rlg
• Allele Name: targeted mutation 1, Richard L Gallo
• Allele ID: MGI:2182791
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Camp^tm1Rlg/Camp^tm1Rlg	129X1(B6)-Camp^tm1Rlg/Kini	MGI:3639339
hm2	Camp^tm1Rlg/Camp^tm1Rlg	involves: 129X1/SvJ * C57BL/6	MGI:3639329
ht3	Camp^tm1Rlg/Camp^+	involves: 129X1/SvJ * C57BL/6	MGI:3639330

Genotype
MGI:3639339

hm1

• Allelic Composition: Camp^tm1Rlg/Camp^tm1Rlg
• Genetic Background: 129X1(B6)-Camp^tm1Rlg/Kini

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to bacterial infection induced morbidity/mortality ( J:109553 )

• homozygotes with urinary tract infection (caused by E.coli infection) show increased mortality, with 3 of 18 dying from septicemia compared to none of wild-type

immune system

increased susceptibility to bacterial infection ( J:109553 )

• increased susceptibility to uropathogenic E. coli infection; exhibit a higher infection rate (increased presence of bacteria in urinary tract) and higher numbers of bacteria attached to bladders and surviving on epithelial cells after 30 min

• homozygotes with urinary tract infection exhibit higher number of bacteria in kidneys and larger size of kidneys and have more severe systemic signs of infection such as weight loss and increased mortality

increased susceptibility to bacterial infection induced morbidity/mortality ( J:109553 )

• homozygotes with urinary tract infection (caused by E.coli infection) show increased mortality, with 3 of 18 dying from septicemia compared to none of wild-type

Genotype
MGI:3639329

hm2

• Allelic Composition: Camp^tm1Rlg/Camp^tm1Rlg
• Genetic Background: involves: 129X1/SvJ * C57BL/6

immune system

increased neutrophil cell number ( J:199719 )

• in the cornea of mice infected with F. solani

increased incidence of corneal inflammation ( J:199719 )

• in mice infected with F. solani

increased susceptibility to bacterial infection ( J:72924 )

• homozygotes are more susceptible to Group A Streptococcus infection, developing larger areas of infection and showing a more rapid increase in lesion areas and longer persistence of lesions

increased susceptibility to fungal infection ( J:199719 )

• mice infected with F. solani exhibit more rapid development of keratitis (cornea cloudiness and edema), increased neutrophil infiltration (determined by MPO activity and plate count) and enhanced fungal load without recovery compared with wild-type mice

vision/eye

increased incidence of corneal inflammation ( J:199719 )

• in mice infected with F. solani

hematopoietic system

increased neutrophil cell number ( J:199719 )

• in the cornea of mice infected with F. solani

Genotype
MGI:3639330

ht3

• Allelic Composition: Camp^tm1Rlg/Camp⁺
• Genetic Background: involves: 129X1/SvJ * C57BL/6

immune system

increased susceptibility to bacterial infection ( J:72924 )

• heterozygotes are more susceptible to Group A Streptococcus infection, developing intermediate sized lesions