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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Eomestm1Apr
targeted mutation 1, Andreas P Russ
MGI:2182814
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Eomestm1Apr/Eomestm1Apr Not Specified MGI:3687957
ht2
 		Eomestm1Apr/Eomes+ involves: C57BL/6 MGI:3687958
cx3
 		Eomestm1Apr/Eomes+
Tbx21tm1Srnr/Tbx21tm1Srnr 		involves: C57BL/6 MGI:3687959


Genotype
MGI:3687957
hm1
Allelic
Composition		 Eomestm1Apr/Eomestm1Apr
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eomestm1Apr mutation (0 available); any Eomes mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

embryo
embryonic growth arrest ( J:60897 )
• embryos arrest soon after implantation and fail to form embryonic or extraembryonic structures (examined at E6 and E7.5)
abnormal egg cylinder morphology ( J:60897 )
• in chimeras with wild-type tetraploids, embryos still resemble enlarged egg cylinders without mesoderm at E8.5
absent mesoderm ( J:60897 )
• in chimeras with wild-type tetraploids, posterior thickening of epiblast occurs with signs of epithelial to mesenchymal transition but no embryonic or extraembryonic mesoderm
abnormal anterior primitive streak morphology ( J:60897 )
• differentiation of anterior streak and node is blocked
absent primitive node ( J:60897 )
• in chimeras with wild-type tetraploids, a distinct node is absent at E7.5
abnormal primitive streak elongation ( J:60897 )
• in chimeras with wild-type tetraploids, elongation of the primitive streak is absent at E7.5
abnormal trophoblast layer morphology ( J:60897 )
• no trophoblast outgrowth from cultured blastocysts




Genotype
MGI:3687958
ht2
Allelic
Composition		 Eomestm1Apr/Eomes+
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eomestm1Apr mutation (0 available); any Eomes mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased NK cell number ( J:112679 )
• lymphoid tissues considerably depleted of natural killer cells
decreased memory T cell number ( J:112679 )
• depleted CD8+ memory T cells

hematopoietic system
decreased NK cell number ( J:112679 )
• lymphoid tissues considerably depleted of natural killer cells
decreased memory T cell number ( J:112679 )
• depleted CD8+ memory T cells




Genotype
MGI:3687959
cx3
Allelic
Composition		 Eomestm1Apr/Eomes+
Tbx21tm1Srnr/Tbx21tm1Srnr
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eomestm1Apr mutation (0 available); any Eomes mutation (44 available)
Tbx21tm1Srnr mutation (0 available); any Tbx21 mutation (39 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased NK cell number ( J:112679 )
• partial loss of natural killer cells
decreased NK T cell number ( J:112679 )
• lymphoid tissues considerably depleted of NK-T cells
decreased memory T cell number ( J:112679 )
• depleted CD8+ memory T cells
decreased interferon-gamma secretion ( J:112679 )
• defective Ifng production by CD8+ cells in vitro

hematopoietic system
decreased NK cell number ( J:112679 )
• partial loss of natural killer cells
decreased NK T cell number ( J:112679 )
• lymphoid tissues considerably depleted of NK-T cells
decreased memory T cell number ( J:112679 )
• depleted CD8+ memory T cells




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory