Analysis Tools
mortality/aging
|
• slightly fewer than expected mice are found at 3 weeks
|
cellular
|
• enhanced 4-fold in white adipose tissue and increased in brown adipose tissue
|
|
• glomeruli exhibit diffuse mesangial hypercellularity
|
|
• anti-IgM stimulated B cells exhibit a 2- to 3-fold decrease in proliferation compared with wild-type cells
|
|
• anti-CD40 treated splenocytes B220+ splenocytes is slightly enhanced compared to similarly treated wild-type cells
|
reproductive system
|
• female mice bred with wild-type mice produce smaller than expected litters
|
immune system
|
• in 30% of mice at 7 to 12 months
|
|
• in older mice
|
|
• spleen cellularity is increased 2-fold in older mice compared to in wild-type mice
• mice exhibit an expansion of Ter119+HSA+ lymphocytes on the spleen compared with wild-type mice
|
|
• young and old mice exhibit lymph node hyperplasia due to an increase in B220+ cells compared to in wild-type mice
|
|
• CD4+ T cells exhibit increased levels of memory markers compared with wild-type cells
|
|
• spleens often exhibit follicular expansion due to enlarged follicular cells compared to in wild-type mice
|
|
• in 30% of mice at 7 to 12 months
|
|
• young and old mice exhibit lymph node hyperplasia due to an increase in B220+ cells compared to in wild-type mice
|
|
• at 5 to 12 months, 85% of mice exhibit some immunological disorders unlike wild-type mice
|
|
• anti-IgM stimulated B cells exhibit a 2- to 3-fold decrease in proliferation compared with wild-type cells
|
|
• anti-CD40 treated splenocytes B220+ splenocytes is slightly enhanced compared to similarly treated wild-type cells
|
|
• parietal salivary glands exhibit lymphocytic infiltrates unlike in wild-type mice
|
|
• T-cell-dependent IgG1 and IgG2a response to NP-KLH are 7.5-fold and 9.5-fold, respectively, compared with wild-type mice
|
|
• 17 days after treatment with NP-Ficoll, mice exhibit 3.5-fold lower serum IgG3 levels compared with similarly treated wild-type mice
|
|
• 17 days after treatment with NP-Ficoll, mice exhibit 4-fold lower IgM serum levels compared with similarly treated wild-type mice
|
|
• concanavalin A or ati-CD3 antibody treated splenocytes produce 3-fold more IFN-gamma compared with similarly treated wild-type mice
• Th1 cells produce 3-fold more IFN-gamma than wild-type cells
• following TCR cross-linking, T cells produce more IFN-gamma than similarly treated wild-type cells
|
|
• Th2 cells produce 3-fold more IL4 than wild-type cells
• following TCR cross-linking, T cells produce more IL4 than similarly treated wild-type cells
|
|
• kidneys exhibit lymphocytic infiltrates unlike in wild-type mice
|
|
• mice exhibit membranoproliferative glomerulonephritis
|
|
• lungs exhibit lymphocytic infiltrates unlike in wild-type mice
|
homeostasis/metabolism
|
• 25% at 7 weeks
|
|
• 5-fold when mice are fed a high-fat diet
|
|
• when mice are fed a high-fat diet
|
|
• when mice are fed a high-fat diet
|
|
• 27% when fed a high fat diet
|
|
• in male mice
|
|
• insulin-stimulated glucose infusion rate and turnover are increased compared to in wild-type mice
|
hypoglycemia
(
J:120128
)
|
• mildly under fed conditions
|
|
• 5-fold when mice are fed a high-fat diet and also decreased when mice are fed normal chow
|
|
• enhanced 35%
|
|
• in females
|
|
• mild to severe in 29% of males and 17% of females
|
|
• in 33% of males and 45% of females
|
|
• 7% when fed a high fat diet
|
renal/urinary system
|
• thickening of the capillary walls
|
|
• glomeruli exhibit diffuse mesangial hypercellularity
|
|
• mild to severe in 29% of males and 17% of females
|
|
• in 33% of males and 45% of females
|
|
• kidneys exhibit lymphocytic infiltrates unlike in wild-type mice
|
|
• mice exhibit membranoproliferative glomerulonephritis
|
|
• glomeruli are hypercellular and lobulated unlike in wild-type mice
|
adipose tissue
|
• BAT mass is reduced even when mice are fed a high-fat diet
(J:163905)
|
|
• in the epididymal fat pads at 12 weeks
(J:120128)
• WAT mass is reduced even when mice are fed a high-fat diet
(J:163905)
|
|
• 14% compared to 23% in wild-type mice
|
|
• enhanced 4-fold in white adipose tissue and increased in brown adipose tissue
|
digestive/alimentary system
|
• 30% of mice exhibit colorectal prolapse
• 41% of aged females and 18% of aged males exhibit colorectal prolapse
|
|
• parietal salivary glands exhibit lymphocytic infiltrates unlike in wild-type mice
|
growth/size/body
|
• by 20% at E13.5
|
|
• 25% to 30%
(J:68830)
• 20%
(J:120128)
|
|
• 8%
|
|
• after 7 weeks on a high-fat diet, mice do not gain weight
|
|
• in male mice
|
|
• in 30% of mice at 7 to 12 months
|
|
• in older mice
|
|
• spleen cellularity is increased 2-fold in older mice compared to in wild-type mice
• mice exhibit an expansion of Ter119+HSA+ lymphocytes on the spleen compared with wild-type mice
|
endocrine/exocrine glands
|
• parietal salivary glands exhibit lymphocytic infiltrates unlike in wild-type mice
|
respiratory system
|
• lungs exhibit lymphocytic infiltrates unlike in wild-type mice
|
hematopoietic system
|
• anti-IgM stimulated B cells exhibit a 2- to 3-fold decrease in proliferation compared with wild-type cells
|
|
• anti-CD40 treated splenocytes B220+ splenocytes is slightly enhanced compared to similarly treated wild-type cells
|
|
• in 30% of mice at 7 to 12 months
|
|
• in older mice
|
|
• spleen cellularity is increased 2-fold in older mice compared to in wild-type mice
• mice exhibit an expansion of Ter119+HSA+ lymphocytes on the spleen compared with wild-type mice
|
|
• young and old mice exhibit lymph node hyperplasia due to an increase in B220+ cells compared to in wild-type mice
|
|
• CD4+ T cells exhibit increased levels of memory markers compared with wild-type cells
|
|
• spleens often exhibit follicular expansion due to enlarged follicular cells compared to in wild-type mice
|
|
• 17 days after treatment with NP-Ficoll, mice exhibit 3.5-fold lower serum IgG3 levels compared with similarly treated wild-type mice
|
|
• 17 days after treatment with NP-Ficoll, mice exhibit 4-fold lower IgM serum levels compared with similarly treated wild-type mice
|
behavior/neurological
|
• 2-fold when fed a high fat diet
|
embryo
|
• by 20% at E13.5
|
liver/biliary system
|
• resistance to the onset of hepatic steatosis in aged mice fed normal chow
|
cardiovascular system
|
• thickening of the capillary walls
|
