Phenotypes associated with this allele

• Allele Symbol: Lepr^db-NCSU
• Allele Name: diabetes, North Carolina State University
• Allele ID: MGI:2182820
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lepr^db-NCSU/Lepr^db-NCSU	involves: CD-1	MGI:3813269

Genotype
MGI:3813269

hm1

• Allelic Composition: Lepr^db-NCSU/Lepr^db-NCSU
• Genetic Background: involves: CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:60363 )

• male mice die at 5 months of age

reproductive system

female infertility ( J:60363 )

♀

male infertility ( J:60363 )

♂

growth/size/body

obese ( J:60363 )

• female mice are heavier than normal starting at day 7

• male mice are heavier than normal starting at day 35 but exhibit a sharp drop in weight beginning at day 56 to 70 and lasting 4 months

• however, by day 84 male mice exhibit normal weight

homeostasis/metabolism

increased circulating glucose level ( J:60363 )

• at 2 months of age blood glucose levels are 2-fold higher in males and 1.5-fold higher in females compared to in wild-type mice

increased circulating insulin level ( J:60363 )

• at 4 months of age, in female mice exhibit increased serum insulin levels compared to wild-type mice

• however, insulin levels in male mice are normal

increased circulating leptin level ( J:60363 )

• beginning at 4 months of age

increased urine glucose level ( J:60363 )

• mice exhibit a urinary glucose concentration of greater than 2000 mg/dl

• age of onset of glycosuria is related to weight gain

insulin resistance ( J:60363 )

• at 2 months of age

behavior/neurological

polydipsia ( J:60363 )

• mice drink 4 times as much as wild-type mice

polyphagia ( J:60363 )

renal/urinary system

increased urine glucose level ( J:60363 )

• mice exhibit a urinary glucose concentration of greater than 2000 mg/dl

• age of onset of glycosuria is related to weight gain