Analysis Tools
immune system
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• in vitro B cell proliferation in response to anti-IgM, anti-CD40, or LPS is enhanced 3- to 4- fold
• enhanced cell division progression and decreased apoptosis contribute to the increased proliferative response
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• CD4 T cell hyperproliferate in response to TCR stimulation
• proliferation is enhanced 2- to 4-fold in response to anti-TCR or anti-TCR/anti-CD28 stimulation compared to controls
• CD4 T cells from pre-immunized mice proliferate at a 35-fold higher rate than controls when cultured with antigen in vitro
• hyperproliferation is intrinsic to the CD4 T cells as increased proliferation is still observed when mutant T cells is incubated with wild-type APC
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• germinal centers in the spleen of immunized mice are larger
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• there is a large increase in IgG1 levels compared to controls when mice are immunized with a T cell-dependent antigen
• significantly higher IgG1 titers result from immunization with T cell dependent antigens
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• significantly higher IgG2a titers result from immunization with T cell dependent antigens
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• there is a large increase in IgG2b levels compared to controls when mice are immunized with a T cell-dependent antigen
• significantly higher IgG2b titers result from immunization with a T cell dependent antigen
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• there is a large increase in IgG3 levels compared to controls when mice are immunized with a T cell-dependent antigen
• significantly higher IgG2b titers result from immunization with a T cell dependent antigen
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• there is a modest increase in IgM levels compared to controls when mice are immunized with a T cell-dependent antigen
• significantly higher IgM titers result from immunization with T cell dependent antigens
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• CD4 T cells activated under Th1 polarizing conditions continue to produce the Th2 cytokine IL-4
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• nave CD4 T cells secrete about 5-fold more Th2 cytokines than controls when activated by TCR stimulus
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• nave CD4 T cells secrete about 5-fold more IL-10 than controls when activated
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• nave CD4 T cells secrete about 5-fold more IL-13 than controls when activated
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• nave CD4 T cells secrete about 5-fold more IL-4 than controls when activated
• similar results occur when CD4 T cells are activated under Th2 polarizing conditions
• when activated under Th1 polarizing conditions, CD4 T cells produce 300-fold more IL-4 than control Th1 cells
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• nave CD4 T cells secrete about 5-fold more IL-5 than controls when activated
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hematopoietic system
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• in vitro B cell proliferation in response to anti-IgM, anti-CD40, or LPS is enhanced 3- to 4- fold
• enhanced cell division progression and decreased apoptosis contribute to the increased proliferative response
|
|
• CD4 T cell hyperproliferate in response to TCR stimulation
• proliferation is enhanced 2- to 4-fold in response to anti-TCR or anti-TCR/anti-CD28 stimulation compared to controls
• CD4 T cells from pre-immunized mice proliferate at a 35-fold higher rate than controls when cultured with antigen in vitro
• hyperproliferation is intrinsic to the CD4 T cells as increased proliferation is still observed when mutant T cells is incubated with wild-type APC
|
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• germinal centers in the spleen of immunized mice are larger
|
|
• there is a large increase in IgG1 levels compared to controls when mice are immunized with a T cell-dependent antigen
• significantly higher IgG1 titers result from immunization with T cell dependent antigens
|
|
• significantly higher IgG2a titers result from immunization with T cell dependent antigens
|
|
• there is a large increase in IgG2b levels compared to controls when mice are immunized with a T cell-dependent antigen
• significantly higher IgG2b titers result from immunization with a T cell dependent antigen
|
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• there is a large increase in IgG3 levels compared to controls when mice are immunized with a T cell-dependent antigen
• significantly higher IgG2b titers result from immunization with a T cell dependent antigen
|
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• there is a modest increase in IgM levels compared to controls when mice are immunized with a T cell-dependent antigen
• significantly higher IgM titers result from immunization with T cell dependent antigens
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• CD4 T cells activated under Th1 polarizing conditions continue to produce the Th2 cytokine IL-4
|
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• nave CD4 T cells secrete about 5-fold more Th2 cytokines than controls when activated by TCR stimulus
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cellular
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• in vitro B cell proliferation in response to anti-IgM, anti-CD40, or LPS is enhanced 3- to 4- fold
• enhanced cell division progression and decreased apoptosis contribute to the increased proliferative response
|
|
• CD4 T cell hyperproliferate in response to TCR stimulation
• proliferation is enhanced 2- to 4-fold in response to anti-TCR or anti-TCR/anti-CD28 stimulation compared to controls
• CD4 T cells from pre-immunized mice proliferate at a 35-fold higher rate than controls when cultured with antigen in vitro
• hyperproliferation is intrinsic to the CD4 T cells as increased proliferation is still observed when mutant T cells is incubated with wild-type APC
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