Analysis Tools
mortality/aging
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• homozygotes die within 24 hours of birth
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homeostasis/metabolism
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• mild to severe edema after E15 in about 25% of homozygotes
• edema usually appears as subdermal swelling as early as E15 and a mildly turgid trunk and appendages at E18
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growth/size/body
omphalocele
(
J:70294
)
|
• ~30% of mice are born with an omphalocele or herniation of the gut into the umbilical cord
• 13 or 14 of embryos exhibit omphalocele up to E17, unlike wild-type embryos which show complete resolution of physiologic omphalocele by E15 or E16;
~70% of these mice resolve the omphalocele prior to birth
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renal/urinary system
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• lack foot processes
|
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• lack slit diaphragms
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cardiovascular system
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• measured in embryos as a 15 fold increase in RBC released from a severed umbilical artery as compared to control embryos
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