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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(GFP/KRAS2/ALPP)1Brn
transgene insertion 1, Anton Berns
MGI:2182853
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Tg(GFP/KRAS2/ALPP)1Brn/0 		involves: 129P2/OlaHsd * FVB/N MGI:3765975
cn2
 		Braftm1Rima/Braf+
Tg(GFP/KRAS2/ALPP)1Brn/0
Tg(Tyr-cre/ERT2)1Lru/0 		involves: C57BL/6 * DBA/2 * FVB/N MGI:4458351


Genotype
MGI:3765975
cn1
Allelic
Composition		 Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Tg(GFP/KRAS2/ALPP)1Brn/0
Genetic
Background		 involves: 129P2/OlaHsd * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm2(cre/ERT2)Brn mutation (1 available); any Gt(ROSA)26Sor mutation (993 available)
Tg(GFP/KRAS2/ALPP)1Brn mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased keratoacanthoma incidence ( J:127226 )
• upon induction with 4-hydroxytamoxifen (4-OHTA), 2/4 mice develop regional keratoacanthomas at site of drug application within 8 weeks
increased lymphoma incidence ( J:127226 )
• 2/4 induced animals acquire lymphoma
increased lung tumor incidence ( J:127226 )
• 2/4 induced animals acquire lung tumors

integument
increased keratoacanthoma incidence ( J:127226 )
• upon induction with 4-hydroxytamoxifen (4-OHTA), 2/4 mice develop regional keratoacanthomas at site of drug application within 8 weeks

respiratory system
increased lung tumor incidence ( J:127226 )
• 2/4 induced animals acquire lung tumors




Genotype
MGI:4458351
cn2
Allelic
Composition		 Braftm1Rima/Braf+
Tg(GFP/KRAS2/ALPP)1Brn/0
Tg(Tyr-cre/ERT2)1Lru/0
Genetic
Background		 involves: C57BL/6 * DBA/2 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Braftm1Rima mutation (0 available); any Braf mutation (60 available)
Tg(GFP/KRAS2/ALPP)1Brn mutation (1 available)
Tg(Tyr-cre/ERT2)1Lru mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased melanoma incidence ( J:161180 )
• tamoxifen-treated mice exhibit rapid onset of melanoma with a median onset at 2 months and 100% penetrance within 3 months




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory