Analysis Tools
reproductive system
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• doubled number of corpora lutea at 12 weeks of age, putatively due to impaired degeneration
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• relatively dilated ovaries at 12 weeks of age
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uterus cyst
(
J:70023
)
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• at 12 weeks of age, the uterine lumen is filled with numerous proliferative cysts of various sizes
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• extruded endometria with comb-like structure at 6 weeks of age
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• extremely dilated uteri exhibited at 5 weeks of age
• widely opened lumen filled with proliferative cysts at 12 weeks of age
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• prostaglandin accumulation in the uterus
• 2-fold increase in uterine levels of PGE2 relative to wild-type
• 2-fold increase in uterine levels of 6-keto PGF1alpha relative to wild-type
• 3-fold increase in uterine levels of PGF2alpha relative to wild-type, urine levels were normal
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• 70% decrease in incidence of pregnancy compared to wild-type
• the decreased incidence of pregnancy is not rescued by superovulation
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• 50% decrease in the number of offspring due to embryonic lethality; 100% of embryos were alive at E11, 10-20% of of embryos were dead at E14, and 60% of of embryos were dead at E20
• near average size litters were produced by superovulating females
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homeostasis/metabolism
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N |
• normal estradiol levels detected in urine
• normal progesterone levels detected in urine
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• prostaglandin accumulation in the uterus
• 2-fold increase in uterine levels of PGE2 relative to wild-type
• 3-fold increase in uterine levels of PGF2alpha relative to wild-type, urine levels were normal
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endocrine/exocrine glands
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• doubled number of corpora lutea at 12 weeks of age, putatively due to impaired degeneration
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• relatively dilated ovaries at 12 weeks of age
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growth/size/body
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• relatively dilated ovaries at 12 weeks of age
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uterus cyst
(
J:70023
)
|
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• at 12 weeks of age, the uterine lumen is filled with numerous proliferative cysts of various sizes
|
