Phenotypes associated with this allele

• Allele Symbol: Faah^tm1Crv
• Allele Name: targeted mutation 1, Benjamin F Cravatt
• Allele ID: MGI:2182901
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Faah^tm1Crv/Faah^tm1Crv	B6.129X1-Faah^tm1Crv	MGI:3629984
hm2	Faah^tm1Crv/Faah^tm1Crv	involves: 129X1/SvJ * C57BL/6	MGI:3629992
cx3	Faah^tm1Crv/Faah^tm1Crv Tg(SOD1*G93A)1Gur/0	involves: 129X1/SvJ * ABH * C57BL/6 * SJL	MGI:4881741

Genotype
MGI:3629984

hm1

• Allelic Composition: Faah^tm1Crv/Faah^tm1Crv
• Genetic Background: B6.129X1-Faah^tm1Crv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:109633 )

N • female mutant mice have increased ethanol metabolism compared to male mutants or male wild-type; blood ethanol levels are lower in female mutants at 30, 60 and 90 minutes after consumption

decreased body temperature ( J:109633 )

• female mutants are less sensitive to hypothermic effects of alcohol

• after treatment with anandamide (EAE), mutants show a time dependent hypothermia compared to wild-type

behavior/neurological

alcohol preference ( J:109633 )

• female mutants show a preference for ethanol compared to wild-type male mice and male mutants with greatest significance at 12% and 20% ethanol concentrations

increased alcohol consumption ( J:109633 )

• female mutants consume 30-35% more of 12% and 20% ethanol than controls

• female mutants consume 70% more of 12% and 53% more of 20 % ethanol than male mutants

improved righting response ( J:109633 )

• female mutants are more resistant to sedative effects of alcohol, regaining their righting reflex faster than female or male wild-type or male mutants

increased chemically-elicited antinociception ( J:109633 )

• mutants exhibit enhanced antinociception after anandamide treatment compared to wild-type

Genotype
MGI:3629992

hm2

• Allelic Composition: Faah^tm1Crv/Faah^tm1Crv
• Genetic Background: involves: 129X1/SvJ * C57BL/6

homeostasis/metabolism

decreased body temperature ( J:70666 )

• after treatment with anandamide (EAE), mutants show a time dependent hypothermia compared to wild-type

behavior/neurological

decreased locomotor activity ( J:70666 )

• mutants exhibit hypomotility compared to wild-type

increased chemical nociceptive threshold ( J:70666 )

• in the formalin test, Faah-deficient mice exhibit a reduction in pain behavior during the first phase of the formalin reaction compared to wild-type

increased chemically-elicited antinociception ( J:70666 )

• mutants exhibit enhanced antinociception after anandamide treatment compared to wild-type; profound analgesia is shown in the tail immersion test (89% of maximum response)

increased thermal nociceptive threshold ( J:70666 )

• mutants exhibit prolonged response latencies in tail immersion and hot plate tests compared to wild-type or heterozygotes

catalepsy ( J:70666 )

• Faah-deficient mice (88%) display catalepsy in the bar test

Genotype
MGI:4881741

cx3

• Allelic Composition: Faah^tm1Crv/Faah^tm1Crv; Tg(SOD1*G93A)1Gur/0
• Genetic Background: involves: 129X1/SvJ * ABH * C57BL/6 * SJL

mortality/aging

premature death ( J:111498 )

• similar to in Tg(SOD1*G93A)1Gur mice

muscle

abnormal muscle physiology ( J:111498 )

• mice exhibit increased muscle force and motor unit survival compared with Tg(SOD1*G93A)1Gur mice

nervous system

motor neuron degeneration ( J:111498 )

• mice exhibit less motor neuron degeneration compared with Tg(SOD1*G93A)1Gur mice