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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mtf1tm1Wsc
targeted mutation 1, Walter Schaffner
MGI:2182939
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Mtf1tm1Wsc/Mtf1tm1Wsc involves: 129 * C57BL/6 MGI:2656942
hm2
 		Mtf1tm1Wsc/Mtf1tm1Wsc Not Specified MGI:3046549
cn3
 		Mtf1tm1Wsc/Mtf1tm1Wsc
Tg(Mx1-cre)1Cgn/0
Tg(UBC-Mtf1)1Wsc/0 		involves: 129/Sv * C57BL/6 * CBA MGI:3046551
cx4
 		Mtf1tm1Wsc/Mtf1tm1Wsc
Tg(UBC-Mtf1)1Wsc/0 		Not Specified MGI:3046550


Genotype
MGI:2656942
hm1
Allelic
Composition		 Mtf1tm1Wsc/Mtf1tm1Wsc
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mtf1tm1Wsc mutation (0 available); any Mtf1 mutation (38 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
lethality throughout fetal growth and development, complete penetrance ( J:48216 )
• normal ratio of homozygotes present up to E13.5 but no viable embryos after E14.5

liver/biliary system
hepatic necrosis ( J:48216 )
• although liver size was normal and there were no indications of apoptosis, liver damage was present at E13.5
• severe liver necrosis at E14.5 with diffuse bleeding and generalized edema in the only surviving embryo examined at E14.5

cellular
increased cellular sensitivity to alkylating agents ( J:48216 )
• increased susceptibility of embryo fibroblasts to cadmium and hydrogen peroxide




Genotype
MGI:3046549
hm2
Allelic
Composition		 Mtf1tm1Wsc/Mtf1tm1Wsc
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mtf1tm1Wsc mutation (0 available); any Mtf1 mutation (38 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
lethality throughout fetal growth and development, complete penetrance ( J:91119 )
• embryos die around E14 due to liver degeneration

liver/biliary system
hepatic necrosis ( J:91119 )
• embryonic liver degeneration with irregular patches of necrotic cells is seen
• mutant hepatocytes in primary culture are less viable compared to wild-type hepatocytes

cardiovascular system




Genotype
MGI:3046551
cn3
Allelic
Composition		 Mtf1tm1Wsc/Mtf1tm1Wsc
Tg(Mx1-cre)1Cgn/0
Tg(UBC-Mtf1)1Wsc/0
Genetic
Background		 involves: 129/Sv * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mtf1tm1Wsc mutation (0 available); any Mtf1 mutation (38 available)
Tg(Mx1-cre)1Cgn mutation (7 available)
Tg(UBC-Mtf1)1Wsc mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
increased susceptibility to xenobiotic induced morbidity/mortality ( J:91119 )
• exposure to cadmium was lethal for all male and 2 out of 3 female mutants after induction of cre mediated recombination compared to no male and only 1 female (out of 4) death in mutants without the cre transgene

homeostasis/metabolism
increased susceptibility to xenobiotic induced morbidity/mortality ( J:91119 )
• exposure to cadmium was lethal for all male and 2 out of 3 female mutants after induction of cre mediated recombination compared to no male and only 1 female (out of 4) death in mutants without the cre transgene
increased physiological sensitivity to xenobiotic ( J:91119 )
• cadmium exposure resulted in cell degeneration and necrosis in the liver, lung, and pancreas in all male mutants and some of the female mutants after induction of cre mediated recombination
abnormal xenobiotic pharmacokinetics ( J:91119 )
• transgenic mice after induction of cre accumulate less cadmium in the liver and kidneys compared to control transgenic mice that do not carry the cre transgene

immune system
decreased leukocyte cell number ( J:91119 )
• transgenic mice after induction of cre have one third of the number of white blood cells compared to control transgenic mice that do not carry the cre transgene
decreased lymphocyte cell number ( J:91119 )
• the lymphocyte population in particular is severely reduced in transgenic mice after induction of cre compared to control transgenic mice that do not carry the cre transgene

hematopoietic system
decreased leukocyte cell number ( J:91119 )
• transgenic mice after induction of cre have one third of the number of white blood cells compared to control transgenic mice that do not carry the cre transgene
decreased lymphocyte cell number ( J:91119 )
• the lymphocyte population in particular is severely reduced in transgenic mice after induction of cre compared to control transgenic mice that do not carry the cre transgene




Genotype
MGI:3046550
cx4
Allelic
Composition		 Mtf1tm1Wsc/Mtf1tm1Wsc
Tg(UBC-Mtf1)1Wsc/0
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mtf1tm1Wsc mutation (0 available); any Mtf1 mutation (38 available)
Tg(UBC-Mtf1)1Wsc mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:91119 )
• presence of the transgene rescues the null phenotype




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Send questions and comments to User Support. 		last database update
10/22/2024
MGI 6.24 		The Jackson Laboratory