Analysis Tools
homeostasis/metabolism
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• at 20 min after i.v. administration of [14C]-TEA (0.2 mg/kg), homozygotes show a 1.5-fold increase in the amount of TEA found in urine relative to wild-type controls
• at 60 min after i.v. administration of [14C]-TEA (0.2 mg/kg), fully anesthetized homozygotes with a cannulated gallbladder show a similar 1.5-fold increase in cumulative excretion of [14C]-TEA in urine relative to wild-type controls
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• at 20 min after i.v. administration of 0.2 mg/kg [14C]-tetraethylammonium (TEA; a model compound for small, relatively hydrophilic cations), homozygotes show a >6-fold reduction of [14C]-TEA accumulation in the liver relative to wild-type controls; however, no significant differences in TEA levels are detected in brain, spleen or plasma relative to similarly treated wild-type controls
• at 60 min after i.v. injection of [14C]-TEA (0.2 mg/kg), fully anesthetized homozygotes with a cannulated gallbladder show a ~4-fold reduction of [14C]-TEA accumulation in the liver relative to wild-type controls; however, levels of [14C]-TEA in cecum and colon contents are similar to those in wild-type controls
• at 60 min after i.v. administration of [14C]-TEA (0.2 mg/kg), fully anesthetized homozygotes with a cannulated gallbladder show a 2.5-fold decrease in cumulative excretion of [14C]-TEA in bile relative to wild-type controls
• at 20 min after i.v. administration of [14C]-TEA (0.2 mg/kg), homozygotes show a 6- to 10-fold reduction of TEA excretion levels into the lumen of the small intestine, cecum, and colon relative to wild-type controls
• at 20 min after i.v. administration of [14C]-TEA (0.2 mg/kg), homozygotes show a 1.5-fold increase in the amount of TEA found in urine relative to wild-type controls
• at 60 min after i.v. administration of [14C]-TEA (0.2 mg/kg), fully anesthetized homozygotes with a cannulated gallbladder show a similar 1.5-fold increase in cumulative excretion of [14C]-TEA in urine relative to wild-type controls
• at 60 min after i.v. injection of [14C]TEA (0.2 mg/kg), fully anesthetized homozygotes with a cannulated gallbladder show a 2-fold decrease in direct small intestinal excretion of [14C]TEA relative to wild-type controls
• at 30 min after i.v. administration of [3H]MPP+ (a neurotoxin) or [125I]MIBG (an anticancer drug), each at 1 mg/kg, hepatic uptake of [3H]MPP+ and [125I]MIBG is reduced ~60% and 75%, respectively; however, no differences in plasma, spleen, or small intestinal excretion of these organic cations are observed relative to similarly treated wild-type controls
• no significant differences are observed following i.v. administration in the distribution of [3H]cimetidine and [14C]choline to the liver or other organs
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liver/biliary system
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• at 60 min after i.v. administration of [14C]-TEA (0.2 mg/kg), fully anesthetized homozygotes with a cannulated gallbladder show a 2.5-fold decrease in cumulative excretion of [14C]-TEA in bile relative to wild-type controls
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• at 20 min after i.v. administration of [14C]-TEA (0.2 mg/kg), homozygotes show a >6-fold reduction of [14C]-TEA accumulation in the liver relative to wild-type controls; however, no significant differences in TEA levels are detected in brain, spleen or plasma relative to similarly treated wild-type controls
• at 60 min after i.v. injection of [14C]-TEA (0.2 mg/kg), fully anesthetized homozygotes with a cannulated gallbladder show a ~4-fold reduction of [14C]-TEA accumulation in the liver relative to wild-type controls; however, levels of [14C]-TEA in cecum and colon contents are similar to those in wild-type controls
• at 30 min after i.v. administration of [3H]MPP+ (a neurotoxin) or [125I]MIBG (an anticancer drug), each at 1 mg/kg, hepatic uptake of [3H]MPP+ and [125I]MIBG is reduced ~60% and 75%, respectively; however, no differences in plasma, spleen, or small intestinal excretion of these organic cations are observed relative to similarly treated wild-type controls
• no significant differences are observed following i.v. administration in the distribution of [3H]cimetidine and 14C]choline to the liver or other organs
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digestive/alimentary system
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• at 20 min after i.v. administration of [14C]-TEA (0.2 mg/kg), homozygotes show a 6- to 10-fold reduction of TEA excretion levels into the lumen of the small intestine, cecum, and colon relative to wild-type controls
• at 60 min after i.v. injection of [14C]TEA (0.2 mg/kg), fully anesthetized homozygotes with a cannulated gallbladder show a 2-fold decrease in direct small intestinal excretion of [14C]TEA relative to wild-type controls
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renal/urinary system
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• at 20 min after i.v. administration of [14C]-TEA (0.2 mg/kg), homozygotes show a 1.5-fold increase in the amount of TEA found in urine relative to wild-type controls
• at 60 min after i.v. administration of [14C]-TEA (0.2 mg/kg), fully anesthetized homozygotes with a cannulated gallbladder show a similar 1.5-fold increase in cumulative excretion of [14C]-TEA in urine relative to wild-type controls
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