Analysis Tools
immune system
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• in response to OVA-induced pulmonary inflammation, homozygotes show no significant differences in airway recruitment of eosinophils relative to wild-type mice, with equivalent changes in BAL cellularity, and maximal recruitment of eosinophils occurring in both genotypes at 48 hrs after the final aerosol challenge
• in response to OVA sensitization/challenge, homozygotes display normal histopathologic pulmonary changes, with an identical increase in PAS-positive airway epithelial mucus staining in bronchi and bronchioles relative to similarly-treated wild-type mice
• in addition, OVA-sensitized/challenged wild-type and homozygous mutant mice exhibit identical increases in methacholine-induced airflow changes relative to saline-challenged control groups, indicating that OVA-induced airway hyperresponsiveness (AHR) in response to nonspecific stimuli remains unaffected
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• when eosinophils from peritoneal cavity exudates of M. Corti (parasite) Ag-sensitized/challenged mice are examined at the ultrastructural level, secondary granules from homozygous mutant eosinophils are ~57% the size of wild-type granules, indicating that the area of the electron translucent matrix and, thus, size of the secondary granule itself is dependent on the physical presence of EPO
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hematopoietic system
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• when eosinophils from peritoneal cavity exudates of M. Corti (parasite) Ag-sensitized/challenged mice are examined at the ultrastructural level, secondary granules from homozygous mutant eosinophils are ~57% the size of wild-type granules, indicating that the area of the electron translucent matrix and, thus, size of the secondary granule itself is dependent on the physical presence of EPO
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