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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Hrh1Bphs-s
B pertussis induced histamine sensitization, susceptible
MGI:2182953
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Hrh1Bphs-s/Hrh1Bphs-s C3.SJL-Hrh1Bphs-s MGI:5610042
ht2
 		Hrh1Bphs-r/Hrh1Bphs-s (C3H/HeJ x SJL/J)F1 MGI:5610127


Genotype
MGI:5610042
hm1
Allelic
Composition		 Hrh1Bphs-s/Hrh1Bphs-s
Genetic
Background		 C3.SJL-Hrh1Bphs-s
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hrh1Bphs-s mutation (0 available); any Hrh1 mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal response to infection ( J:77938 )
• hypersensitivity to agents and treatments that affect the vascular bed
increased susceptibility to bacterial infection induced morbidity/mortality ( J:77938 )
• mice sensitized to Bordetella pertussis toxin (PTX) show clinical signs of induced histamine-elicited vasoactive amine sensitization (VAASH)

mortality/aging
increased susceptibility to bacterial infection induced morbidity/mortality ( J:77938 )
• mice sensitized to Bordetella pertussis toxin (PTX) show clinical signs of induced histamine-elicited vasoactive amine sensitization (VAASH)




Genotype
MGI:5610127
ht2
Allelic
Composition		 Hrh1Bphs-r/Hrh1Bphs-s
Genetic
Background		 (C3H/HeJ x SJL/J)F1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hrh1Bphs-r mutation (2 available); any Hrh1 mutation (36 available)
Hrh1Bphs-s mutation (0 available); any Hrh1 mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal immune system physiology ( J:77938 )
• mice are susceptible to experimental allergic encephalomyelitis (EAE)
• males mice are susceptible to experimental allergic orchitis (EAO)
• hypersensitivity to agents and treatments that affect the vascular bed
increased susceptibility to bacterial infection induced morbidity/mortality ( J:77938 )
• mice sensitized to Bordetella pertussis toxin (PTX) show clinical signs of induced histamine-elicited vasoactive amine sensitization (VAASH)
• death due to experimental sensitivity occurred within 30 minutes

mortality/aging
increased susceptibility to bacterial infection induced morbidity/mortality ( J:77938 )
• mice sensitized to Bordetella pertussis toxin (PTX) show clinical signs of induced histamine-elicited vasoactive amine sensitization (VAASH)
• death due to experimental sensitivity occurred within 30 minutes




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory