Phenotypes associated with this allele

• Allele Symbol: Fabp5^tm1Kdo
• Allele Name: targeted mutation 1, Hisatake Kondo
• Allele ID: MGI:2182961
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fabp5^tm1Kdo/Fabp5^tm1Kdo	involves: C57BL/6	MGI:3618344

Genotype
MGI:3618344

hm1

• Allelic Composition: Fabp5^tm1Kdo/Fabp5^tm1Kdo
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

impaired skin barrier function ( J:75715 )

• homozygotes are viable, fertile and grossly normal, with no significant differences in the epidermal content of major fatty acids or in the population density of lamellar bodies and their exocytotic features after acetone treatment

• untreated homozygotes display a 50% reduction in basal transepidermal water loss relative to wild-type mice

• following acetone treatment, homozygotes show a delayed recovery of the epidermal water barrier, although maximum transepidermal water loss is comparable to that of wild-type mice in terms of size and time course

• unlike wild-type mice, adult homozygotes show a significantly increased mRNA expression level of the heart-type fatty acid binding protein in the skin and liver

immune system

immune system phenotype ( J:75715 )

N • homozygotes exhibit a normal inflammatory response to arachidonic acid treatment, with a similar degree of increase in ear thickness relative to wild-type mice

integument

impaired skin barrier function ( J:75715 )

• homozygotes are viable, fertile and grossly normal, with no significant differences in the epidermal content of major fatty acids or in the population density of lamellar bodies and their exocytotic features after acetone treatment

• untreated homozygotes display a 50% reduction in basal transepidermal water loss relative to wild-type mice

• following acetone treatment, homozygotes show a delayed recovery of the epidermal water barrier, although maximum transepidermal water loss is comparable to that of wild-type mice in terms of size and time course

• unlike wild-type mice, adult homozygotes show a significantly increased mRNA expression level of the heart-type fatty acid binding protein in the skin and liver