Phenotypes associated with this allele

• Allele Symbol: Mapk8ip1^tm1Wae
• Allele Name: targeted mutation 1, Gerard Waeber
• Allele ID: MGI:2182967
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mapk8ip1^tm1Wae/Mapk8ip1^tm1Wae	either: (involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6) or (involves: 129P2/OlaHsd * C57BL/6)	MGI:3618377
ht2	Mapk8ip1^tm1Wae/Mapk8ip1^+	either: (involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6) or (involves: 129P2/OlaHsd * C57BL/6)	MGI:3618379

Genotype
MGI:3618377

hm1

• Allelic Composition: Mapk8ip1^tm1Wae/Mapk8ip1^tm1Wae
• Genetic Background: either: (involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6) or (involves: 129P2/OlaHsd * C57BL/6)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality before implantation, complete penetrance ( J:70600 )

• homozygotes die prior to blastocyst implantation, with less than 1% of mutant embryos surviving to E3.5

• early embryonic lethality is attributed to poor survival of fertilized mutant oocytes

cellular

abnormal cell death ( J:70600 )

• in culture, no homozygous mutant embryos are identified as early as two-cell stage, indicating accelerated cell death during the first cell cycles

Genotype
MGI:3618379

ht2

• Allelic Composition: Mapk8ip1^tm1Wae/Mapk8ip1⁺
• Genetic Background: either: (involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6) or (involves: 129P2/OlaHsd * C57BL/6)

reproductive system

reproductive system phenotype ( J:70600 )

N • despite observed RNA and protein expression in wild-type unfertilized oocytes and spermatozoa, heterozygotes exhibit normal fertility relative to wild-type mice

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:70600 )

N • on regular chow, heterozygotes display normal glucose homeostasis, with no significant differences in pancreas histology or fasting plasma levels of glucose and insulin relative to wild-type mice