All Phenotypes Lgals3<tm1Poi> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lgals3^tm1Poi/Lgals3^tm1Poi	B6.Cg-Lgals3^tm1Poi/J	MGI:6195175
hm2	Lgals3^tm1Poi/Lgals3^tm1Poi	involves: 129 * C57BL/6J * SJL	MGI:3789007
hm3	Lgals3^tm1Poi/Lgals3^tm1Poi	involves: 129S/SvEv	MGI:5615613
hm4	Lgals3^tm1Poi/Lgals3^tm1Poi	involves: 129/Sv * C57BL/6 * MF1 * SJL	MGI:3789175
hm5	Lgals3^tm1Poi/Lgals3^tm1Poi	involves: 129/Sv * C57BL/6 * SJL	MGI:3789081
cx6	Lgals1^tm1Rob/Lgals1^tm1Rob Lgals3^tm1Poi/Lgals3^tm1Poi	involves: 129S/SvEv * C57BL/6J * SJL	MGI:3789006
cx7	Apoe^tm1Unc/Apoe^tm1Unc Lgals3^tm1Poi/Lgals3^tm1Poi	involves: 129/Sv * C57BL/6 * SJL	MGI:3789127

Allelic Composition	Lgals3^tm1Poi/Lgals3^tm1Poi
Genetic Background	B6.Cg-Lgals3^tm1Poi/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lgals3^tm1Poi mutation (4 available); any Lgals3 mutation (29 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

adipose tissue

increased total body fat amount ( J:264129 )

• 6-7 month old mice exhibit an increase in adiposity

behavior/neurological

abnormal stationary movement ( J:264129 )

• 2-3 and 6-7 month old mice exhibit less total movement compared to wild-type mice, especially during the circadian dark cycle

decreased locomotor activity ( J:264129 )

• 2-3 and 6-7 month old mice exhibit decreased movement-in-place behaviors due to decreased bout numbers, initiation rates, and durations

• 6-7 month old mice exhibit decreased forward locomotion due to decreased bout numbers, initiation rates, and durations

abnormal circadian behavior ( J:264129 )

• 2-3 and 6-7 month old mice exhibit perturbed behavioral circadian rhythms, with greater day-to-day variability in feeding, drinking, and movement

growth/size/body

increased body weight ( J:264129 )

• 6-7, but not 2-3, month old mice exhibit greater body weights

skeleton

increased bone mineral density ( J:264129 )

• 6-7 month old mice exhibit an increase in bone mineral density

Allelic Composition	Lgals3^tm1Poi/Lgals3^tm1Poi
Genetic Background	involves: 129 * C57BL/6J * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lgals3^tm1Poi mutation (4 available); any Lgals3 mutation (29 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:47227 )

N	• mice exhibit a normal lifespan

reproductive system

reproductive system phenotype ( J:47227 )

N	• mice exhibit normal reproduction

integument

integument phenotype ( J:47227 )

N	• mice exhibit normal skin structure

Allelic Composition	Lgals3^tm1Poi/Lgals3^tm1Poi
Genetic Background	involves: 129S/SvEv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lgals3^tm1Poi mutation (4 available); any Lgals3 mutation (29 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

impaired cued conditioning behavior ( J:217719 )

aggression towards inanimate objects ( J:217719 )

abnormal social/conspecific interaction behavior ( J:217719 )

• social dominance

Allelic Composition	Lgals3^tm1Poi/Lgals3^tm1Poi
Genetic Background	involves: 129/Sv * C57BL/6 * MF1 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lgals3^tm1Poi mutation (4 available); any Lgals3 mutation (29 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased granulocyte number ( J:110422 )

• while recruitment of granulocytes following treatment with thioglycolate is normal, granulocyte numbers 3 to 4 days after treatment are reduced 4-fold compared to in wild-type mice

• however, granulocyte apoptosis rates and phagocytosis of apoptotic granulocytes are normal

immune system

decreased granulocyte number ( J:110422 )

• while recruitment of granulocytes following treatment with thioglycolate is normal, granulocyte numbers 3 to 4 days after treatment are reduced 4-fold compared to in wild-type mice

• however, granulocyte apoptosis rates and phagocytosis of apoptotic granulocytes are normal

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:131407 )

• mice infected with S. pneumoniae exhibit high mortality after 24 hours

immune system

impaired neutrophil recruitment ( J:131407 )

• 15 hours after infection with S. pneumoniae

• however, myeloperoxidase activity is similar to in wild-type mice 15 hours after infection with S. pneumoniae

abnormal macrophage physiology ( J:131971 )

• macrophage activation by IL-4 and IL-13 stimulation Is impaired

• however, macrophage activation by IFN-gamma and LPS is normal

impaired macrophage chemotaxis ( J:131971 )

• when stimulated by IL-4 and IL-13

impaired macrophage phagocytosis ( J:131407 )

• phagocytosis of apoptotic neutrophils by bone marrow-derived macrophages is impaired

• however, phagocytosis of S. pneumonia is normal

increased interleukin-6 secretion ( J:131407 )

• 15 hours after infection with S. pneumoniae, IL-6 concentration in bronchoalveolar lavage is increased compared to in wild-type mice

increased tumor necrosis factor secretion ( J:131407 )

• 15 hours after infection with S. pneumoniae, TNF-alpha concentration in bronchoalveolar lavage is increased compared to in wild-type mice

lung inflammation ( J:131407 )

• after 15 hours, mice infected with S. pneumoniae exhibit increased cell infiltrate in the lungs and develop severe pneumonia with increased lung injury and septicemia compared to wild-type mice

increased susceptibility to bacterial infection ( J:131407 )

• mice infected with S. pneumoniae exhibit high mortality after 24 hours

• after 15 hours, mice infected with S. pneumoniae exhibit increased cell infiltrate but decreased total cell counts in the lungs and develop severe pneumonia with increased lung injury and septicemia compared to wild-type mice

• after 15 hours, mice infected with S. pneumoniae exhibit a 450-fold increase in bacterial load compared to wild-type mice and blood cultures indicate 100 % bacteremia compared to 30% in wild-type mice

sepsis ( J:131407 )

• after 15 hours, mice infected with S. pneumoniae exhibit septicemia unlike wild-type mice

skeleton

abnormal long bone epiphyseal plate morphology ( J:66902 )

• unlike in wild-type mice, a large zone of empty lacunae is observed between the last row of hypertrophic cells and the vascular invasion front

abnormal long bone hypertrophic chondrocyte zone ( J:66902 )

• chondrocytes within the hypertrophic zone are larger and more vacuolated than in wild-type mice

• mice exhibit an increased number of nonhypertrophic cells in the late hyprtrophic zone compared to in wild-type mice

• chondrocytes in the zone contain unusually large intracellular glycogen aggregates

decreased width of hypertrophic chondrocyte zone ( J:66902 )

• the hypertrophic zone is reduced in size and contains 20% fewer hypertrophic cells than in wild type mice

renal/urinary system

abnormal kidney physiology ( J:131371 )

• mice exhibit less renal fibrosis following unilateral ureter obstruction (UUO) compared to wild-type mice

• however, macrophage recruitment and cytokine production induced by UUO is normal

respiratory system

lung inflammation ( J:131407 )

• after 15 hours, mice infected with S. pneumoniae exhibit increased cell infiltrate in the lungs and develop severe pneumonia with increased lung injury and septicemia compared to wild-type mice

homeostasis/metabolism

decreased susceptibility to injury ( J:131371 )

• mice exhibit less renal fibrosis following unilateral ureter obstruction (UUO) compared to wild-type mice

• however, macrophage recruitment and cytokine production induced by UUO is normal

cellular

impaired macrophage chemotaxis ( J:131971 )

• when stimulated by IL-4 and IL-13

impaired macrophage phagocytosis ( J:131407 )

• phagocytosis of apoptotic neutrophils by bone marrow-derived macrophages is impaired

• however, phagocytosis of S. pneumonia is normal

hematopoietic system

impaired neutrophil recruitment ( J:131407 )

• 15 hours after infection with S. pneumoniae

• however, myeloperoxidase activity is similar to in wild-type mice 15 hours after infection with S. pneumoniae

abnormal macrophage physiology ( J:131971 )

• macrophage activation by IL-4 and IL-13 stimulation Is impaired

• however, macrophage activation by IFN-gamma and LPS is normal

impaired macrophage chemotaxis ( J:131971 )

• when stimulated by IL-4 and IL-13

impaired macrophage phagocytosis ( J:131407 )

• phagocytosis of apoptotic neutrophils by bone marrow-derived macrophages is impaired

• however, phagocytosis of S. pneumonia is normal

Allelic Composition	Lgals1^tm1Rob/Lgals1^tm1Rob Lgals3^tm1Poi/Lgals3^tm1Poi
Genetic Background	involves: 129S/SvEv * C57BL/6J * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lgals1^tm1Rob mutation (5 available); any Lgals1 mutation (20 available)
Lgals3^tm1Poi mutation (4 available); any Lgals3 mutation (29 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:47227 )

N	• mice exhibit a normal lifespan

reproductive system

reproductive system phenotype ( J:47227 )

N	• mice exhibit normal reproduction

integument

integument phenotype ( J:47227 )

N	• mice exhibit normal skin structure

Allelic Composition	Apoe^tm1Unc/Apoe^tm1Unc Lgals3^tm1Poi/Lgals3^tm1Poi
Genetic Background	involves: 129/Sv * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoe^tm1Unc mutation (33 available); any Apoe mutation (158 available)
Lgals3^tm1Poi mutation (4 available); any Lgals3 mutation (29 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

decreased susceptibility to atherosclerosis ( J:130923 )

• at 25 to 31 weeks of age, mice exhibit a lower number inflammatory infiltrate and mast cells in adventitia than Apoe^tm1Unc homozygotes

• at 36 to 44 months of age, mice exhibit fewer atherosclerotic lesions and atheromatous plaques compared to in Apoe^tm1Unc homozygotes and do not exhibit an age-related increase in lesion number, athlerosclerotic microaneurysms or periaortic vascular channels that are evident in Apoe^tm1Unc homozygotes

homeostasis/metabolism

increased circulating cholesterol level ( J:130923 )

• compared to in Lgals3^tm1Poi homozygotes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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