Analysis Tools
homeostasis/metabolism
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• potentiation in Purkinje cells is reduced in response to treatment with diazepam unlike wild-type cells
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behavior/neurological
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• diazepam-treated mice fail to exhibit a complete suppression of pentylenetetrazole-induced tonic convulsion unlike in similarly treated wild-type mice
• however, mice respond normally to the anti-convulsant effects of phenobarbital
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• in a passive avoidance or modified lick suppression paradigm, diazepam-treated mice fail to exhibit amnesic effects unlike similarly treated wild-type mice
• however, mice exhibit the myorelaxant, motor-impairing, ethanol-potentiating and anxiolytic-like properties of diazepam, normal amnesic effects of the muscarinic antagonist scopolamine, and normal anti-convulsant effects of phenobarbital
• diazepam-treated mice fail to exhibit a complete suppression of pentylenetetrazole-induced tonic convulsion unlike in similarly treated wild-type mice
• mice fail to exhibit sedation following treatment with diazepam and are resistant to the sedative effects of zolpidem unlike wild-type mice
• however, response to non-benzodiazepines is normal
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• in a passive avoidance paradigm, diazepam-treated mice fail to exhibit a reduction in latency to enter the dark compartment after training unlike similarly treated wild-type mice
• in a modified lick suppression paradigm, diazepam-treated mice fail to exhibit a reduced recall latency unlike wild-type mice
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nervous system
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• diazepam-treated mice fail to exhibit a complete suppression of pentylenetetrazole-induced tonic convulsion unlike in similarly treated wild-type mice
• however, mice respond normally to the anti-convulsant effects of phenobarbital
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