About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gabra2tm1Uru
targeted mutation 1, Uwe Rudolph
MGI:2183161
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Gabra2tm1Uru/Gabra2tm1Uru
Tg(Scn10a-cre)1Rkun/0 		involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * DBA/2 MGI:5140579
cn2
 		Gabra2tm1Uru/Gabra2tm2.1Uru
Tg(Scn10a-cre)1Rkun/0 		involves: C57BL/6 * DBA/2 * SJL MGI:5140581


Genotype
MGI:5140579
cn1
Allelic
Composition		 Gabra2tm1Uru/Gabra2tm1Uru
Tg(Scn10a-cre)1Rkun/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gabra2tm1Uru mutation (0 available); any Gabra2 mutation (36 available)
Tg(Scn10a-cre)1Rkun mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
decreased chemically-elicited antinociception ( J:173378 )
• diazepam (DZP)-treated mice exhibit a profound reduction in the antihyperalgesia effect on inflammatory and neuropathic thermal and mechanical hyperalgesia compared with similarly treated wild-type mice

homeostasis/metabolism
decreased physiological sensitivity to xenobiotic ( J:173378 )
• diazepam (DZP)-treated mice exhibit a profound reduction in the antihyperalgesia effect on inflammatory and neuropathic thermal and mechanical hyperalgesia compared with similarly treated wild-type mice




Genotype
MGI:5140581
cn2
Allelic
Composition		 Gabra2tm1Uru/Gabra2tm2.1Uru
Tg(Scn10a-cre)1Rkun/0
Genetic
Background		 involves: C57BL/6 * DBA/2 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gabra2tm1Uru mutation (0 available); any Gabra2 mutation (36 available)
Gabra2tm2.1Uru mutation (1 available); any Gabra2 mutation (36 available)
Tg(Scn10a-cre)1Rkun mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
decreased chemically-elicited antinociception ( J:173378 )
• diazepam (DZP)-treated mice exhibit a reduction in the antihyperalgesia effect on inflammatory mechanical hyperalgesia compared with similarly treated wild-type mice that is not as severe as in Gabra2tm1Uru/Gabra2tm1Uru Tg(Scn10a-cre)1Rkun
• however, DZP-induced analgesia of neuropathic mechanical nociception is normal

homeostasis/metabolism
decreased physiological sensitivity to xenobiotic ( J:173378 )
• diazepam (DZP)-treated mice exhibit a reduction in the antihyperalgesia effect on inflammatory mechanical hyperalgesia compared with similarly treated wild-type mice that is not as severe as in Gabra2tm1Uru/Gabra2tm1Uru Tg(Scn10a-cre)1Rkun
• however, DZP-induced analgesia of neuropathic mechanical nociception is normal




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory