Phenotypes associated with this allele

• Allele Symbol: Ephb4^tm1And
• Allele Name: targeted mutation 1, David J Anderson
• Allele ID: MGI:2183162
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ephb4^tm1And/Ephb4^tm1And	involves: 129S7/SvEvBrd * C57BL/6J	MGI:3687749

Genotype
MGI:3687749

hm1

• Allelic Composition: Ephb4^tm1And/Ephb4^tm1And
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:57908 )

• growth retardation, arrested heart development and lack of blood flow by E9.5-E10

• degeneration and necrosis by E10.5

embryo

embryonic growth retardation ( J:57908 )

• apparent at E9.5-E10

abnormal vitelline vascular remodeling ( J:57908 )

• remodeling defects most severe at the primitive plexus stage around E9.5

• most severe "on the venous side"

cardiovascular system

abnormal angiogenesis ( J:57908 )

• problems remodeling blood vessels apparently independent of heart defects

failure of vascular branching ( J:57908 )

• fine branching of the head vasculature not seen at E9.5-10 but extensive fusion of the capillary network

• both arterial and venous intersomatic vessels fused and truncated

abnormal vein development ( J:57908 )

• failure to remodel multiple small vessels into a single larger vessel

abnormal anterior cardinal vein morphology ( J:57908 )

• development of the anterior cardinal vein is disrupted

abnormal heart morphology ( J:57908 )

absent myocardial trabeculae ( J:57908 )

• failure of myocardial trabeculation by E10

failure of heart looping ( J:57908 )

• incomplete heart looping at E7.5-9 but heartbeat and blood flow still detectable

abnormal endocardium morphology ( J:57908 )

• endocardium fails to expand

small heart ( J:57908 )

• heart fails to enlarge between E9 and E9.5

growth/size/body

embryonic growth retardation ( J:57908 )

• apparent at E9.5-E10

muscle

absent myocardial trabeculae ( J:57908 )

• failure of myocardial trabeculation by E10