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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gabra2tm1.1Uru
targeted mutation 1.1, Uwe Rudolph
MGI:2183163
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Gabra2tm1.1Uru/Gabra2tm1.1Uru 129-Gabra2tm1.1Uru MGI:3614390


Genotype
MGI:3614390
hm1
Allelic
Composition		 Gabra2tm1.1Uru/Gabra2tm1.1Uru
Genetic
Background		 129-Gabra2tm1.1Uru
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gabra2tm1.1Uru mutation (1 available); any Gabra2 mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal GABA-mediated receptor currents ( J:65100 )
• in hippocampal pyramidal cells potentiation by daizepam of responses to GABA is reduced

behavior/neurological
impaired behavioral response to xenobiotic ( J:65100 )
• diazepam fails to elicit an anxiolytic effect in the elevated-plus-maze test
• however, the sedative, motor-impairing, and anticonvulsant actions of diazepam are all normal




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory