Phenotypes associated with this allele

• Allele Symbol: Neurog1^tm1And
• Allele Name: targeted mutation 1, David J Anderson
• Allele ID: MGI:2183171
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Neurog1^tm1And/Neurog1^tm1And	involves: 129S7/SvEvBrd * C57BL/6	MGI:3527491
cx2	Neurog1^tm1And/Neurog1^tm1And Neurog2^tm3(Ascl1)Fgu/Neurog2^tm3(Ascl1)Fgu	involves: 129S1/Sv * 129X1/SvJ	MGI:3639866
cx3	Neurog1^tm1And/Neurog1^tm1And Neurog2^tm2Fgu/Neurog2^tm2Fgu	involves: 129/Sv * C57BL/6J * CD-1	MGI:3622997

Genotype
MGI:3527491

hm1

• Allelic Composition: Neurog1^tm1And/Neurog1^tm1And
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:46668 )

• homozygotes die within 12 hours of birth

behavior/neurological

abnormal suckling behavior ( J:46668 )

• failed to suckle

nervous system

abnormal cranial ganglia morphology ( J:46668 )

abnormal superior glossopharyngeal ganglion morphology ( J:46668 )

• superior ganglion lost after E10.5

absent trigeminal ganglion ( J:46668 )

• absent at E10.5

abnormal superior vagus ganglion morphology ( J:46668 )

• jugular ganglion lost after E10.5

abnormal cranial nerve morphology ( J:46668 )

abnormal accessory nerve morphology ( J:46668 )

• lost at some time after E10.5 (either the nerve or its ganglion)

abnormal trigeminal nerve morphology ( J:46668 )

• truncated at E10.5

Genotype
MGI:3639866

cx2

• Allelic Composition: Neurog1^tm1And/Neurog1^tm1And; Neurog2^{tm3(Ascl1)Fgu}/Neurog2^{tm3(Ascl1)Fgu}
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

nervous system

abnormal dorsal root ganglion morphology ( J:74525 )

• no differentiation of DRG neurons is seen in double mutants

Genotype
MGI:3622997

cx3

• Allelic Composition: Neurog1^tm1And/Neurog1^tm1And; Neurog2^tm2Fgu/Neurog2^tm2Fgu
• Genetic Background: involves: 129/Sv * C57BL/6J * CD-1

nervous system

abnormal neuron differentiation ( J:59428 )

• neuronal patterning is abnomal in the thalamus, indicating misspecification of neurons; a population of ventral neurons in the dorsal tetncephalon are of dorsal origin

abnormal thalamus morphology ( J:59428 )

• the dorsal thalamus of double mutants is abnormal with an enlargement of the ventricular zone and a reduction in the size of the mantle zone

• neuronal patterning is abnomal in the thalamus, indicating misspecification of neurons

• at E12.5, there is an increase in the number of cells expressing a pan-neuronal marker compared to wild-type

cellular

abnormal neuron differentiation ( J:59428 )

• neuronal patterning is abnomal in the thalamus, indicating misspecification of neurons; a population of ventral neurons in the dorsal tetncephalon are of dorsal origin