Phenotypes associated with this allele

• Allele Symbol: Hdac1^tm1Sei
• Allele Name: targeted mutation 1, Christian Seiser
• Allele ID: MGI:2183177
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hdac1^tm1Sei/Hdac1^tm1Sei	either: (involves: 129P2/OlaHsd * 129/Sv) or (involves: 129P2/OlaHsd * C57BL/6)	MGI:3622924
ht2	Hdac1^tm1Sei/Hdac1^+	either: (involves: 129P2/OlaHsd * 129/Sv) or (involves: 129P2/OlaHsd * C57BL/6)	MGI:3622927

Genotype
MGI:3622924

hm1

• Allelic Composition: Hdac1^tm1Sei/Hdac1^tm1Sei
• Genetic Background: either: (involves: 129P2/OlaHsd * 129/Sv) or (involves: 129P2/OlaHsd * C57BL/6)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:76941 )

• no homozygotes born

• no live homozygotes after E9.4

embryo

embryonic growth retardation ( J:76941 )

• growth retarded after E7.5

abnormal allantois morphology ( J:76941 )

• severely disturbed allantois formation at E9.5

growth/size/body

embryonic growth retardation ( J:76941 )

• growth retarded after E7.5

abnormal head development ( J:76941 )

• severely disturbed head formation at E9.5

Genotype
MGI:3622927

ht2

• Allelic Composition: Hdac1^tm1Sei/Hdac1⁺
• Genetic Background: either: (involves: 129P2/OlaHsd * 129/Sv) or (involves: 129P2/OlaHsd * C57BL/6)

mortality/aging

prenatal lethality, incomplete penetrance ( J:76941 )

• lower than expected numbers of heterozygous births, but survivors exhibit normal fertility, viability and phenotypic appearance