Analysis Tools|
Allele Symbol Allele Name Allele ID |
Dbptm1Schb targeted mutation 1, Ueli Schibler MGI:2183196 |
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| Summary |
4 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• generate about 40% fewer wheel revolutions and show less spontaneous activity under light/dark conditions
• overall decrease in activity is mostly the result of decreased activity during the dark phase
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• moderately but significantly shorter compared to controls under dark/dark conditions
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• increased liver mass
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• 50% of mice die within the first 2 months of age due to lethal seizures
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• mice are hypersensitive to xenobiotic compounds including pentobarbital
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• a circadian trend of seizure occurance is observed, with 4-times more seizures occuring during early light period hours (major sleep period) than during early dark period hours (major active period)
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• observed in some mice; audiogenic seizures account for about 25% of all deceased mice
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• spontaneous tonic-clonic seizures that occur predominantly within slow-wave sleep during the first 2 min after transition to sleep
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• observe a few absence-like seizures without any sign of EEG hypoactivity
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• a circadian trend of seizure occurance is observed, with 4-times more seizures occuring during early light period hours (major sleep period) than during early dark period hours (major active period)
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• observed in some mice; audiogenic seizures account for about 25% of all deceased mice
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• spontaneous tonic-clonic seizures that occur predominantly within slow-wave sleep during the first 2 min after transition to sleep
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• observe a few absence-like seizures without any sign of EEG hypoactivity
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• reduction in levels of serotonin and dopamine and increase in levels of histamine in the brain
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• analysis of sleep EEG of a 12-hour light period shows a significant increase in slow-wave delta activity and a significant decrease in theta activity
• activity in all frequency bins greater than 15 Hz (the beta frequency range) is significantly increased during all vigilance states
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• increased plasma levels of alanine aminotransferase
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• reduction in levels of dopamine in the brain
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• reduction in the levels of serotonin in the brain
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• mice are hypersensitive to xenobiotic compounds including pentobarbital, mitoxantrone and cyclophosphamide
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• increased liver mass
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• several seizure-like activities are observed in mutants, however they never develop into generalized epilepsies
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• several absence-like seizures without any sign of EEG hypoactivity are seen
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• several seizure-like activities are observed in mutants, however they never develop into generalized epilepsies
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• several absence-like seizures without any sign of EEG hypoactivity are seen
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• analysis of sleep EEG of a 12-hour light period shows an increase in slow-wave delta activity and a decrease in theta activity, however this is much less pronounced than in triple homozygous mutants
• activity in all frequency bins greater than 15 Hz (the beta frequency range) is increased in waking mutants
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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