Phenotypes associated with this allele

• Allele Symbol: Rev3l^tm1Ndew
• Allele Name: targeted mutation 1, Niels De Wind
• Allele ID: MGI:2183197
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rev3l^tm1Ndew/Rev3l^tm1Ndew	involves: 129P2/OlaHsd * C57BL/6	MGI:3840907
cx2	Rev3l^tm1Ndew/Rev3l^tm1Ndew Trp53^tm1Tyj/Trp53^tm1Tyj	involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6	MGI:3840908

Genotype
MGI:3840907

hm1

• Allelic Composition: Rev3l^tm1Ndew/Rev3l^tm1Ndew
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:75450 )

• mutant embryos are present up to 10.5 dpc in a near Mendelian ratio, but live embryos older than 11.5 dpc are not observed

• Background Sensitivity: in pure 129P2/OlaHsd backgrounds, mutant embryos are detectable up to 15.5 dpc

embryo

abnormal embryonic tissue morphology ( J:75450 )

• abnormalities are seen in mutant embryos beginning at 10.5 dpc, when apoptotic cells are detectable in the embryo proper

• by 10.5 dpc, mutant embryos show growth retardation and a wide range of developmental dysmorphology, and considerable apoptotic cell death in the embryo proper compared to controls

cellular

spontaneous chromosome breakage ( J:75450 )

• in cells derived from 11.5 dpc mutant embryos, chromosome and chromatid breaks as well as an increased frequency of translocations are seen in 14% of the cells, compared to 0.7% in controls

Genotype
MGI:3840908

cx2

• Allelic Composition: Rev3l^tm1Ndew/Rev3l^tm1Ndew; Trp53^tm1Tyj/Trp53^tm1Tyj
• Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:75450 )

• mutant embryos are present up to 10.5 dpc in a near Mendelian ratio, but live embryos older than 11.5 dpc are not observed

embryo

abnormal embryonic tissue morphology ( J:75450 )

• abnormalities are seen in double mutant embryos beginning at 10.5 dpc, when apoptotic cells are detectable in the embryo proper

• similar to Rev3l homozygous embryos, by 10.5 dpc, double mutant embryos show growth retardation and a wide range of developmental dysmorphology, and considerable apoptotic cell death in the embryo proper compared to controls