All Phenotypes Ucp3<tm1Rei> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ucp3^tm1Rei
targeted mutation 1, Marc L Reitman
MGI:2183202

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ucp3^tm1Rei/Ucp3^tm1Rei	involves: 129S6/SvEvTac	MGI:3852061
hm2	Ucp3^tm1Rei/Ucp3^tm1Rei	involves: 129S6/SvEvTac * Black Swiss	MGI:3852055
cx3	Ucp1^tm1Kz/Ucp1^tm1Kz Ucp3^tm1Rei/Ucp3^tm1Rei	involves: 129S2/SvPas * 129S6/SvEvTac * Black Swiss	MGI:3852056

Allelic Composition	Ucp3^tm1Rei/Ucp3^tm1Rei
Genetic Background	involves: 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ucp3^tm1Rei mutation (0 available); any Ucp3 mutation (6 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

improved glucose tolerance ( J:142293 )

• when fed a high-fat diet for 2 to 3 months, mice exhibit improved glucose tolerance compared with similarly treated wild-type mice

• however, glucose tolerance after 4 or 8 months on a high fat diet is the same as in similarly treated wild-type mice

increased insulin sensitivity ( J:142293 )

• after 3 and 4 months on a high-fat diet, mice exhibit increased insulin sensitivity compared with similarly treated wild-type mice

• however, after 8 months on a high-fat diet mice exhibit normal insulin sensitivity

adipose tissue

abnormal epididymal fat pad morphology ( J:142293 )

• 21% larger than in wild-type mice when fed a high-fat diet for 8 months

Allelic Composition	Ucp3^tm1Rei/Ucp3^tm1Rei
Genetic Background	involves: 129S6/SvEvTac * Black Swiss

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ucp3^tm1Rei mutation (0 available); any Ucp3 mutation (6 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased circulating glucose level ( J:62312 )

• sometimes slightly when fed a high-fat diet

decreased circulating free fatty acids level ( J:62312 )

• sometimes slightly when fed a high-fat diet

cellular

abnormal mitochondrial physiology ( J:62312 )

• substrate oxidation and oxygen consumption in muscle mitochondria are lower than in wild-type mice

Allelic Composition	Ucp1^tm1Kz/Ucp1^tm1Kz Ucp3^tm1Rei/Ucp3^tm1Rei
Genetic Background	involves: 129S2/SvPas * 129S6/SvEvTac * Black Swiss

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ucp1^tm1Kz mutation (2 available); any Ucp1 mutation (51 available)
Ucp3^tm1Rei mutation (0 available); any Ucp3 mutation (6 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased oxygen consumption ( J:62312 )

• similar to in Ucp1^tm1Kz homozygotes, the respiratory exchange ratio of CL316243-treated mice is less than in similarly treated wild-type mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24