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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ucp3tm1Brnd
targeted mutation 1, Martin D Brand
MGI:2183204
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ucp3tm1Brnd/Ucp3tm1Brnd B6.Cg-Ucp3tm1Brnd MGI:3852052
hm2
 		Ucp3tm1Brnd/Ucp3tm1Brnd Not Specified MGI:3852053


Genotype
MGI:3852052
hm1
Allelic
Composition		 Ucp3tm1Brnd/Ucp3tm1Brnd
Genetic
Background		 B6.Cg-Ucp3tm1Brnd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ucp3tm1Brnd mutation (0 available); any Ucp3 mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal mitochondrial physiology ( J:73905 )
• skeletal muscle mitochondria proton conductance is insensitive to superoxide treatment unlike wild-type mitochondria




Genotype
MGI:3852053
hm2
Allelic
Composition		 Ucp3tm1Brnd/Ucp3tm1Brnd
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ucp3tm1Brnd mutation (0 available); any Ucp3 mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased skeletal muscle triglyceride level ( J:106901 )
• when fed a high-fat diet, intramuscular triglyceride levels are lower than in similarly treated wild-type mice

muscle
decreased skeletal muscle triglyceride level ( J:106901 )
• when fed a high-fat diet, intramuscular triglyceride levels are lower than in similarly treated wild-type mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory