Phenotypes associated with this allele

• Allele Symbol: Pgr^tm1Omc
• Allele Name: targeted mutation 1, Orla M Conneely
• Allele ID: MGI:2183208
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pgr^tm1Omc/Pgr^tm1Omc	involves: 129S7/SvEvBrd * C57BL/6J	MGI:2665492

Genotype
MGI:2665492

hm1

• Allelic Composition: Pgr^tm1Omc/Pgr^tm1Omc
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

uterus hyperplasia ( J:77661 )

♀ • treatment of female homozygotes with estrogen plus progesterone results in a progesterone-dependent increase in uterine epithelial proliferation over that observed with estrogen alone

decreased superovulation rate ( J:77661 )

♀ • following treatment with pregnant mare serum gonadotropin and human chorionic gonadotropin, female homozygotes produce a reduced number of oocytes relative to superovulated wild-type females

abnormal uterine environment ( J:77661 )

♀ • defective uterine implantation is associated with loss of progesterone-regulated expression of a subset of uterine epithelial target genes associated with receptivity

abnormal decidualization ( J:77661 )

♀ • uteri of superovulated female homozygotes fail to exhibit decidualization of stromal cells in response to traumal stimulation

female infertility ( J:77661 )

♀ • female homozygotes appear normal but are infertile

♀ • matings between superovulated female homozygotes and wild-type males fail to result in successful pregnancies although a small number of oocytes is released in mutant females

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:77661 )

N • following estrogen and progesterone treatment, ovariectomized female homozygotes display normal thoracic mammary gland development with extensive hormone-dependent ductal branching and multiple alveolar lobules, as well as normal proliferation and differentiation of the mammary epithelium in response to progesterone

N • also, estrogen- and progesterone-treated ovariectomized female homozygotes exhibit normal thymic involution relative to similarly-treated wild-type females

embryo

abnormal decidualization ( J:77661 )

♀ • uteri of superovulated female homozygotes fail to exhibit decidualization of stromal cells in response to traumal stimulation