Phenotypes associated with this allele

• Allele Symbol: Gfap^tm1Ldtk
• Allele Name: targeted mutation 1, Wolfgang Liedtke
• Allele ID: MGI:2183213
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gfap^tm1Ldtk/Gfap^tm1Ldtk	involves: 129P2/OlaHsd * C57BL/6	MGI:2677143

Genotype
MGI:2677143

hm1

• Allelic Composition: Gfap^tm1Ldtk/Gfap^tm1Ldtk
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal blood-brain barrier function ( J:77630 )

non-obstructive hydrocephaly ( J:77630 )

• at 18-24 months of age, 7 of 14 homozygotes display hydrocephalus ex-vacuo

• however, hydrocephalic homozygotes are neurologically normal and no signs of ependymal erosion, inflammation or subarachnoid hemorrhage are observed

abnormal brain white matter morphology ( J:77630 )

• at >18 months of age, homozygotes display CNS white matter loss

decreased corpus callosum size ( J:77630 )

• at >18 months of age, both hydrocephalic and non-hydrocephalic homozygotes show a significant reduction in corpus callosum thickness

• however, axon density in thinned corpora callosa remains unaltered

abnormal astrocyte morphology ( J:77630 )

abnormal oligodendrocyte morphology ( J:77630 )

abnormal oligodendrocyte physiology ( J:77630 )

abnormal myelination ( J:77630 )

• at >18 months of age, homozygotes exhibit loss of myelinated CNS white matter

cardiovascular system

abnormal blood vessel morphology ( J:77630 )

abnormal blood-brain barrier function ( J:77630 )