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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Fut2tm1Sdo
targeted mutation 1, Steven E Domino
MGI:2183220
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Fut2tm1Sdo/Fut2tm1Sdo B6.129X1-Fut2tm1Sdo MGI:3653037
hm2
 		Fut2tm1Sdo/Fut2tm1Sdo involves: 129X1/SvJ * C57BL/6J MGI:3653036


Genotype
MGI:3653037
hm1
Allelic
Composition		 Fut2tm1Sdo/Fut2tm1Sdo
Genetic
Background		 B6.129X1-Fut2tm1Sdo
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fut2tm1Sdo mutation (1 available); any Fut2 mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal female reproductive system physiology ( J:90993 )
• fucosylated glycans absent in the endocervix and upper vagina

immune system
increased susceptibility to fungal infection ( J:90993 )
• increased susceptibility to vaginal infection with Candida albicans




Genotype
MGI:3653036
hm2
Allelic
Composition		 Fut2tm1Sdo/Fut2tm1Sdo
Genetic
Background		 involves: 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fut2tm1Sdo mutation (1 available); any Fut2 mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal female reproductive system physiology ( J:89929 )
• fucosylated glycolipids absent from female reproductive organs
abnormal uterine environment ( J:72946 )
• absence of fucosylated glycans in the uterine epithelia but normal female fertility

digestive/alimentary system
abnormal digestive system physiology ( J:89929 )
• fucosylated glycolipids absent from the colon




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory