Phenotypes associated with this allele

• Allele Symbol: Tnfrsf11a^tm1Wjb
• Allele Name: targeted mutation 1, William J Boyle
• Allele ID: MGI:2183226
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tnfrsf11a^tm1Wjb/Tnfrsf11a^tm1Wjb	involves: 129X1/SvJ * C57BL/6	MGI:3801016

Genotype
MGI:3801016

hm1

• Allelic Composition: Tnfrsf11a^tm1Wjb/Tnfrsf11a^tm1Wjb
• Genetic Background: involves: 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal mammary gland growth during pregnancy ( J:64718 )

♀ • differentiation and expansion of alveolar buds into mature lobulo-alveolar mammary structures is completely arrested during pregnancy

lactation failure ( J:64718 )

♀ • female mice fail to lactate and pups die after birth regardless of genotype

skeleton

failure of tooth eruption ( J:64718 )

osteopetrosis ( J:64718 )

craniofacial

failure of tooth eruption ( J:64718 )

reproductive system

abnormal mammary gland growth during pregnancy ( J:64718 )

♀ • differentiation and expansion of alveolar buds into mature lobulo-alveolar mammary structures is completely arrested during pregnancy

integument

abnormal mammary gland growth during pregnancy ( J:64718 )

♀ • differentiation and expansion of alveolar buds into mature lobulo-alveolar mammary structures is completely arrested during pregnancy

lactation failure ( J:64718 )

♀ • female mice fail to lactate and pups die after birth regardless of genotype

growth/size/body

failure of tooth eruption ( J:64718 )