Analysis Tools
mortality/aging
|
• about 15% of mice die prior to weaning likely from vertebral or endochondral bone fractures
|
growth/size/body
|
• about 10% of mice are runts for their entire lifespan
|
skeleton
|
• parietal bones of the skull have marked thinning and increased porosity
|
|
• osteoclast surface area is increased by about 3-fold in the tibial metaphyseal with other less dramtic increases observed elsewhere
|
|
• proximal epiphysis of the femur and humerus exhibit resorption of subchondral bone and collapse of the joint surface
|
|
• decreases in bone mineral density are evident by 1 month of age and increase in severity as the mice age
• trabecular bone density in the metaphysis is almost half that of controls at 2 months of age
• cortical bone density in the diaphysis is reduced by more than 10% compared to controls at 2 months of age
|
|
• cortical shafts of the long bones showed increased porosity beginning at about 1 month of age
• cortical bone is composed chiefly of woven bone in adolescents
|
|
• osteoblast-lined bone perimeter as a percentage of total perimeter is also increased in the vertebrae and both the trabecular and cortical regions of the tibiae
|
|
• almost complete absence of trabeculae by 1-2 months of age
|
|
• trabecular area of the proximal tibia is about one/sixth of that found in wild-type mice
|
osteoporosis
(
J:47602
)
|
• mice are osteoporotic with almost complete absence of trabeculae by 1-2 months of age
• loss of cancellous bone and the onset of vertebral osteoporosis are evident within a week after birth and become more severe through adolescent life
• cortical shafts of the long bones showed increased porosity beginning at about 1 month of age
|
|
• vertebral and endochondral bones are often fractured in neonates
• fractures of long bones are observed in older mice
|
cardiovascular system
|
• large arteries including the aorta and in the kidney exhibit some calcification as early as 2 weeks after birth and marked calcification by 2 months of age
|
craniofacial
|
• parietal bones of the skull have marked thinning and increased porosity
|
hematopoietic system
|
• osteoclast surface area is increased by about 3-fold in the tibial metaphyseal with other less dramtic increases observed elsewhere
|
immune system
|
• osteoclast surface area is increased by about 3-fold in the tibial metaphyseal with other less dramtic increases observed elsewhere
|
