Phenotypes associated with this allele

• Allele Symbol: Tacr1^tm1Rhn
• Allele Name: targeted mutation 1, Rene Hen
• Allele ID: MGI:2183231
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tacr1^tm1Rhn/Tacr1^tm1Rhn	129S/SvEv-Tacr1^tm1Rhn	MGI:3846838

Genotype
MGI:3846838

hm1

• Allelic Composition: Tacr1^tm1Rhn/Tacr1^tm1Rhn
• Genetic Background: 129S/SvEv-Tacr1^tm1Rhn

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased circulating corticosterone level ( J:77640 )

• mice exhibit a blunted increase in serum corticosterone levels in an elevated plus maze compared with wild-type mice

abnormal body temperature homeostasis ( J:77640 )

• mice exhibit a reduction in the hypothermic effect caused by 0.16 mg/kg 8-OH-DPAT compared with similarly treated wild-type mice

• however, the hypothermic response induced by higher doses of 8-OH-DPAT is normal

abnormal physiological response to xenobiotic ( J:77640 )

• serotonin neurons exhibit a reduction in the firing inhibition induced by exposure to 8-OH-DPAT that is observed in wild-type neurons

• mice exhibit a reduction in the hypothermic effect caused by 0.16 mg/kg 8-OH-DPAT compared with similarly treated wild-type mice

• however, the hypothermic response induced by higher doses of 8-OH-DPAT is normal

behavior/neurological

impaired behavioral response to xenobiotic ( J:77640 )

• unlike in wild-type mice, RP67580 fails to act as an anxiolytic

• however, diazepam produces normal anxiolytic effects

decreased anxiety-related response ( J:77640 )

• in an elevated plus maze, mice display increased time, percentage of entries, and head dips in the open arms compared with wild-type mice

• however, activity levels are normal

• mice exhibit reduced latency to retrieving food from the center of an open field compared with wild-type mice

hyporesponsive to tactile stimuli ( J:61266 )

• mice exhibit slightly less response to mechanical stimuli at the second highest intensity compared with wild-type mice

increased chemical nociceptive threshold ( J:61266 )

• after formalin injection, mice do not respond during the second phase unlike similarly treated wild-type mice

• however, first phase response to formalin injection is normal

abnormal nociception after inflammation ( J:61266 )

• 21 days after formalin injection, mice exhibit less response to higher intensities of heat or mechanical stimuli compared with similarly treated wild-type mice

decreased vocalization ( J:77640 )

• at P8, mice produce fewer ultrasonic vocalizations compared with wild-type mice

• unlike in wild-type mice, RP67580 fails to act as an anxiolytic

• however, diazepam produces normal anxiolytic effects

nervous system

abnormal neuron physiology ( J:77640 )

• the firing rates of serotonin neurons is increased compared to in wild-type mice

• serotonin neurons exhibit a reduction in the firing inhibition induced by exposure to 8-OH-DPAT that is observed in wild-type neurons

• however, the function of postsynaptic hippocampal 5-HT1A receptors is normal