Analysis Tools
behavior/neurological
polydipsia
(
J:77647
)
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• homozygotes display polydipsia
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renal/urinary system
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• in euhydrated homozygotes, urinary concentration of creatinine is reduced relative to wild-type controls
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• impairment of water reabsorption is observed irrespective of whether water is freely available or withheld
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• in euhydrated homozygotes, urinary concentration of Ca2+ ions is reduced relative to wild-type controls
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• in euhydrated homozygotes, urinary concentration of Cl- ions is reduced relative to wild-type controls
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• in euhydrated homozygotes, urinary concentration of K+ ions is reduced relative to wild-type controls
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• in euhydrated homozygotes, urinary concentration of Na+ ions is reduced relative to wild-type controls
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• at 4 weeks of age, homozygotes are impaired in their urine-concentrating ability relative to wild-type controls
• the urine osmolality of euhydrated mutant mice is about one-third of that in wild-type mice
• after either injection of the V2R agonist dDAVP or water deprivation, homozygotes display only a ~28% increase in urine osmilarity vs a 85% increase in similarly-treated wild-type mice
• however, the total amount of urinary solutes excreted within a 24-hr period is similar to that excreted in wild-type mice, and no significant differences in serum solute or albumin levels are observed
• the urinary concentration of AVP is relatively normal, while the total amount of AVP excreted in a 24-hr period is higher than that excreted in wild-type mice, indicating that AVP synthesis and secretion is unaffected
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• in euhydrated homozygotes, urinary concentration of urea is reduced relative to wild-type controls
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• at 36 weeks of age, the lumens of mutant collecting tubules appear extended
• however, no major kidney abnormalities are noted at 4 or 12 weeks of age, suggesting that renal tubule dilation is probably a consequence of the defect in urine-concentrating ability
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• at 36 weeks of age, the inner medulla of mutant kidneys is abnormal
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homeostasis/metabolism
| N |
• homozygotes show normal blood glucose levels, indicating that polydipsia and polyuria are not due to diabetes mellitus
• synthesis and secretion of the antidiuretic hormone arginine vasopressin (AVP) is normal
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• in euhydrated homozygotes, urinary concentration of creatinine is reduced relative to wild-type controls
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• impairment of water reabsorption is observed irrespective of whether water is freely available or withheld
|
|
• in euhydrated homozygotes, urinary concentration of Ca2+ ions is reduced relative to wild-type controls
|
|
• in euhydrated homozygotes, urinary concentration of Cl- ions is reduced relative to wild-type controls
|
|
• in euhydrated homozygotes, urinary concentration of K+ ions is reduced relative to wild-type controls
|
|
• in euhydrated homozygotes, urinary concentration of Na+ ions is reduced relative to wild-type controls
|
|
• at 4 weeks of age, homozygotes are impaired in their urine-concentrating ability relative to wild-type controls
• the urine osmolality of euhydrated mutant mice is about one-third of that in wild-type mice
• after either injection of the V2R agonist dDAVP or water deprivation, homozygotes display only a ~28% increase in urine osmilarity vs a 85% increase in similarly-treated wild-type mice
• however, the total amount of urinary solutes excreted within a 24-hr period is similar to that excreted in wild-type mice, and no significant differences in serum solute or albumin levels are observed
• the urinary concentration of AVP is relatively normal, while the total amount of AVP excreted in a 24-hr period is higher than that excreted in wild-type mice, indicating that AVP synthesis and secretion is unaffected
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• in euhydrated homozygotes, urinary concentration of urea is reduced relative to wild-type controls
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