cardiovascular system
• reduced autoregulatory efficiency of kidney microvasculature
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• decreased preglomerular arteriolar diameter in males
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• castration reduces high blood pressure of males to normal levels
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• increased mean blood pressure in males
• increased blood pressure is spontaneous and insensitive to dietary salt
• female blood pressure shows less elevation and is more comparable to wild-type male blood pressure
• testosterone or dihydrotestosterone administration increases blood pressure of females and castrated males
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• in males
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• in males
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renal/urinary system
• reduced autoregulatory efficiency of kidney microvasculature
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• decreased preglomerular arteriolar diameter in males
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homeostasis/metabolism
• significantly higher rates of conversion of arachidonic acid to 20-hydroxyarachidonic acid in male kidneys due to up regulation of Cyp4a12
• little 20-hydroxyarachidonic acid activity on female kidneys
• castration reduces conversion of arachidonic acid to 20-hydroxyarachidonic acid in male kidneys
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