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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Cyp4a14tm1Jhc
targeted mutation 1, Jorge H Capdevila
MGI:2183240
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Cyp4a14tm1Jhc/Cyp4a14tm1Jhc involves: 129S6/SvEvTac * 129X1/SvJ MGI:3694693


Genotype
MGI:3694693
hm1
Allelic
Composition
Cyp4a14tm1Jhc/Cyp4a14tm1Jhc
Genetic
Background
involves: 129S6/SvEvTac * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cyp4a14tm1Jhc mutation (1 available); any Cyp4a14 mutation (42 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• reduced autoregulatory efficiency of kidney microvasculature
• decreased preglomerular arteriolar diameter in males
• castration reduces high blood pressure of males to normal levels
• increased mean blood pressure in males
• increased blood pressure is spontaneous and insensitive to dietary salt
• female blood pressure shows less elevation and is more comparable to wild-type male blood pressure
• testosterone or dihydrotestosterone administration increases blood pressure of females and castrated males

renal/urinary system
• reduced autoregulatory efficiency of kidney microvasculature
• decreased preglomerular arteriolar diameter in males

homeostasis/metabolism
• significantly higher rates of conversion of arachidonic acid to 20-hydroxyarachidonic acid in male kidneys due to up regulation of Cyp4a12
• little 20-hydroxyarachidonic acid activity on female kidneys
• castration reduces conversion of arachidonic acid to 20-hydroxyarachidonic acid in male kidneys





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory