Analysis Tools
nervous system
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• exhibit an inhibition of radial growth of the largest caliber axons of L5 dorsal roots; growth of the smallest axons is eliminated, while growth of the largest class continues but at a reduced level
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• exhibit a decrease in the very largest diameter axons and shifts the distribution toward smaller sizes between 4 and 9 weeks of age and by 9 weeks of age, exhibit a 25 and 20% reduction in total axon area of both large and small motor axons, respectively
• by 9 weeks of age, the total number of surviving motor axons is about 13% lower than wild-type, reflecting a preferential loss of large diameter axons (L5 ventral root)
• exhibit a 60% increase in microtubule density in motor axons
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• by 9 weeks of age, the total number of surviving sensory axons is about 19% lower than in wild-type, reflecting a preferential loss of large diameter axons (sensory root)
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cellular
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• exhibit an inhibition of radial growth of the largest caliber axons of L5 dorsal roots; growth of the smallest axons is eliminated, while growth of the largest class continues but at a reduced level
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