Phenotypes associated with this allele

• Allele Symbol: Fancg^tm1Ada
• Allele Name: targeted mutation 1, Alan D'Andrea
• Allele ID: MGI:2183264
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fancg^tm1Ada/Fancg^tm1Ada	involves: 129S4/SvJae * C57BL/6	MGI:3621365

Genotype
MGI:3621365

hm1

• Allelic Composition: Fancg^tm1Ada/Fancg^tm1Ada
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

abnormal ovary morphology ( J:72945 )

♀

abnormal ovarian folliculogenesis ( J:72945 )

♀ • ovaries are almost completely devoid of follicles

abnormal testis morphology ( J:72945 )

♂

abnormal seminiferous tubule morphology ( J:72945 )

♂ • testes are mosaic for normal and abnormal tubules

♂ • abnormal tubules are devoid of spermatocytes,containing only Sertoli cells

decreased testis weight ( J:72945 )

♂ • testis weight is approximately 50% of normal

reduced female fertility ( J:72945 )

♀

infertility ( J:72945 )

• matings of homzygotes maintained for as long as 6 months produce no offspring

reduced male fertility ( J:72945 )

♂

endocrine/exocrine glands

abnormal ovary morphology ( J:72945 )

♀

abnormal ovarian folliculogenesis ( J:72945 )

♀ • ovaries are almost completely devoid of follicles

abnormal testis morphology ( J:72945 )

♂

abnormal seminiferous tubule morphology ( J:72945 )

♂ • testes are mosaic for normal and abnormal tubules

♂ • abnormal tubules are devoid of spermatocytes,containing only Sertoli cells

decreased testis weight ( J:72945 )

♂ • testis weight is approximately 50% of normal

cellular

chromosome breakage ( J:72945 )

• primary splenic lymphocytes, bone marrow progenitor cells, and embryo fibroblast cells show increased sensitivity to mitomycin C and ionizing radiation

spontaneous chromosome breakage ( J:72945 )

• primary splenic lymphocytes, bone marrow progenitor cells, and embryo fibroblasts show spontaneous breakage