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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Diablotm1Mak
targeted mutation 1, Tak Mak
MGI:2183277
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Diablotm1Mak/Diablotm1Mak involves: 129P2/OlaHsd MGI:2672896
cx2
 		Htra2tm1Jdo/Htra2tm1Jdo
Diablotm1Mak/Diablotm1Mak 		involves: 129P/Ola * C57BL/6 MGI:3512687


Genotype
MGI:2672896
hm1
Allelic
Composition		 Diablotm1Mak/Diablotm1Mak
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Diablotm1Mak mutation (1 available); any Diablo mutation (13 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:76248 )
• viable and fertile; no gross morphological or histological abnormalities
• normal induction of apoptosis in UV-irradiated or Fas-antibody treated cells was noted
• mice also exhibit normal T and B cell proliferative responses




Genotype
MGI:3512687
cx2
Allelic
Composition		 Htra2tm1Jdo/Htra2tm1Jdo
Diablotm1Mak/Diablotm1Mak
Genetic
Background		 involves: 129P/Ola * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Diablotm1Mak mutation (1 available); any Diablo mutation (13 available)
Htra2tm1Jdo mutation (0 available); any Htra2 mutation (20 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal stationary movement ( J:94227 )
• progressive movement disorder beginning at P18, identical to the phenotype observed in homozygous Prss25 null mice

cellular
increased apoptosis ( J:94227 )
• increased sensitivity to apoptosis induction by DNA-damaging agent etoposide

growth/size/body
decreased body size ( J:94227 )
decreased body weight ( J:94227 )
• failed to gain weight after P18 and exhibited a phenotype identical to homozygous Prss25 null mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory