All Phenotypes Pten<tm1.1Mro> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Pten^tm1.1Mro
targeted mutation 1.1, Silvia Marino
MGI:2183285

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pten^tm1.1Mro/Pten^tm1.1Mro	involves: BALB/cJ	MGI:3805881
ht2	Pten^tm1.1Mro/Pten⁺	Not Specified	MGI:5812675
cx3	Pten^tm1.1Mro/Pten⁺ Sdhb^tm1.2Ics/Sdhb⁺	involves: 129S2/SvPas * BALB/c * C57BL/6	MGI:5812674

Allelic Composition	Pten^tm1.1Mro/Pten^tm1.1Mro
Genetic Background	involves: BALB/cJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pten^tm1.1Mro mutation (0 available); any Pten mutation (88 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality ( J:77123 )

• authors state that mice exhibit a phenotype that mimicked the phenotype observed in other Pten knockout mice

embryo

abnormal embryo development ( J:77123 )

• authors state that mice exhibit a phenotype that mimicked the phenotype observed in other Pten knockout mice

neoplasm

increased tumor incidence ( J:77123 )

• authors state that mice exhibit a phenotype that mimicked the phenotype observed in other Pten knockout mice

Allelic Composition	Pten^tm1.1Mro/Pten⁺
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pten^tm1.1Mro mutation (0 available); any Pten mutation (88 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

increased pheochromocytoma incidence ( J:236514 )

• at 10 months of age, 73% of mice develop a pheochromocytoma

• tumors do not show accumulation of succinate

neoplasm

increased pheochromocytoma incidence ( J:236514 )

• at 10 months of age, 73% of mice develop a pheochromocytoma

• tumors do not show accumulation of succinate

increased metastatic potential ( J:236514 )

• lung micro-metastasis are seen in 64% of mice

Allelic Composition	Pten^tm1.1Mro/Pten⁺ Sdhb^tm1.2Ics/Sdhb⁺
Genetic Background	involves: 129S2/SvPas * BALB/c * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pten^tm1.1Mro mutation (0 available); any Pten mutation (88 available)
Sdhb^tm1.2Ics mutation (0 available); any Sdhb mutation (29 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

increased pheochromocytoma incidence ( J:236514 )

• at 10 months of age, 80% of mice develop a pheochromocytoma

neoplasm

increased pheochromocytoma incidence ( J:236514 )

• at 10 months of age, 80% of mice develop a pheochromocytoma

increased metastatic potential ( J:236514 )

• lung micro-metastasis are seen in 73% of mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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