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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Cyp26a1tm1.1Hmd
targeted mutation 1.1, Hiroshi Hamada
MGI:2183292
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Cyp26a1tm1.1Hmd/Cyp26a1tm1.1Hmd involves: 129S1/Sv * 129X1/SvJ * C57BL/6Cr MGI:2183555
ht2
Cyp26a1tm1Hmd/Cyp26a1tm1.1Hmd involves: 129S1/Sv * 129X1/SvJ * C57BL/6Cr MGI:2183556


Genotype
MGI:2183555
hm1
Allelic
Composition
Cyp26a1tm1.1Hmd/Cyp26a1tm1.1Hmd
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6Cr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cyp26a1tm1.1Hmd mutation (3 available); any Cyp26a1 mutation (33 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• animals surviving to birth die within 1 day
• fewer than normal numbers survive until birth; abnormalities apparent at E9.5

cardiovascular system
• variable penetrance

digestive/alimentary system
• abnormal digestive system development; terminated at the appendix

embryo
• incomplete axial turning; variable penetrance
• caudal part of body truncated with anterior portion relatively normal
• irregular folding of neural tube
• failure of neural tube closure from the forebrain to the hindbrain in 20% of mice
• irregular somites; variable penetrance

limbs/digits/tail
• fused at midline; variable penetrance
• caudal part of body truncated with anterior portion relatively normal

renal/urinary system
• kidneys often fused; horseshoe kidneys

skeleton
• homeotic transformations of vertebrae

nervous system
N
• normal in 47% of mice
• minor CNS defects in 33% of mice
• irregular folding of neural tube
• failure of neural tube closure from the forebrain to the hindbrain in 20% of mice
• abnormal hindbrain patterning
• variable penetrance




Genotype
MGI:2183556
ht2
Allelic
Composition
Cyp26a1tm1Hmd/Cyp26a1tm1.1Hmd
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6Cr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cyp26a1tm1.1Hmd mutation (3 available); any Cyp26a1 mutation (33 available)
Cyp26a1tm1Hmd mutation (0 available); any Cyp26a1 mutation (33 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
limbs/digits/tail
• variable penetrance and severity
• variable penetrance and severity





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last database update
10/22/2024
MGI 6.24
The Jackson Laboratory