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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cyp26a1tm1.1Hmd
targeted mutation 1.1, Hiroshi Hamada
MGI:2183292
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cyp26a1tm1.1Hmd/Cyp26a1tm1.1Hmd involves: 129S1/Sv * 129X1/SvJ * C57BL/6Cr MGI:2183555
ht2
 		Cyp26a1tm1Hmd/Cyp26a1tm1.1Hmd involves: 129S1/Sv * 129X1/SvJ * C57BL/6Cr MGI:2183556


Genotype
MGI:2183555
hm1
Allelic
Composition		 Cyp26a1tm1.1Hmd/Cyp26a1tm1.1Hmd
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6Cr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cyp26a1tm1.1Hmd mutation (3 available); any Cyp26a1 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
perinatal lethality, complete penetrance ( J:67375 )
• animals surviving to birth die within 1 day
prenatal lethality, incomplete penetrance ( J:67375 )
• fewer than normal numbers survive until birth; abnormalities apparent at E9.5

cardiovascular system
abnormal heart morphology ( J:67375 )
• variable penetrance

digestive/alimentary system
abnormal digestive system development ( J:67375 )
• abnormal digestive system development; terminated at the appendix

embryo
incomplete embryo turning ( J:67375 )
• incomplete axial turning; variable penetrance
sirenomelia ( J:67375 )
• caudal part of body truncated with anterior portion relatively normal
abnormal neural tube morphology ( J:67375 )
• irregular folding of neural tube
open neural tube ( J:119939 )
• failure of neural tube closure from the forebrain to the hindbrain in 20% of mice
abnormal somite development ( J:67375 )
• irregular somites; variable penetrance

limbs/digits/tail
abnormal hindlimb morphology ( J:67375 )
• fused at midline; variable penetrance
sirenomelia ( J:67375 )
• caudal part of body truncated with anterior portion relatively normal

renal/urinary system
fused kidneys ( J:67375 )
• kidneys often fused; horseshoe kidneys

skeleton
vertebral transformation ( J:67375 )
• homeotic transformations of vertebrae

nervous system
nervous system phenotype ( J:119939 )
N
• normal in 47% of mice
abnormal nervous system morphology ( J:119939 )
• minor CNS defects in 33% of mice
abnormal neural tube morphology ( J:67375 )
• irregular folding of neural tube
open neural tube ( J:119939 )
• failure of neural tube closure from the forebrain to the hindbrain in 20% of mice
abnormal hindbrain development ( J:67375 )
• abnormal hindbrain patterning
exencephaly ( J:67375 )
• variable penetrance




Genotype
MGI:2183556
ht2
Allelic
Composition		 Cyp26a1tm1Hmd/Cyp26a1tm1.1Hmd
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6Cr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cyp26a1tm1.1Hmd mutation (3 available); any Cyp26a1 mutation (33 available)
Cyp26a1tm1Hmd mutation (0 available); any Cyp26a1 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
limbs/digits/tail
short tail ( J:67375 )
• variable penetrance and severity
kinked tail ( J:67375 )
• variable penetrance and severity




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory