About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pfn1tm1Wit
targeted mutation 1, Walter Witke
MGI:2183296
Summary 8 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Pfn1tm1Wit/Pfn1tm1Wit B6.129S4-Pfn1tm1Wit MGI:2669617
hm2
 		Pfn1tm1Wit/Pfn1tm1Wit involves: 129S4/SvJae * BALB/c MGI:2669612
hm3
 		Pfn1tm1Wit/Pfn1tm1Wit involves: 129S4/SvJae * C57BL/6 MGI:2669614
ht4
 		Pfn1tm1Wit/Pfn1+ B6.129S4-Pfn1tm1Wit MGI:2669618
ht5
 		Pfn1tm1Wit/Pfn1+ involves: 129S4/SvJae * BALB/c MGI:2669613
ht6
 		Pfn1tm1Wit/Pfn1+ involves: 129S4/SvJae * C57BL/6 MGI:2669615
cx7
 		Ldlrtm1Her/Ldlrtm1Her
Pfn1tm1Wit/Pfn1+ 		B6.129S-Ldlrtm1Her Pfn1tm1Wit MGI:4367099
cx8
 		Enahtm1Fbg/Enahtm1Fbg
Pfn1tm1Wit/Pfn1+ 		involves: 129S4/SvJae MGI:3718223


Genotype
MGI:2669617
hm1
Allelic
Composition		 Pfn1tm1Wit/Pfn1tm1Wit
Genetic
Background		 B6.129S4-Pfn1tm1Wit
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pfn1tm1Wit mutation (0 available); any Pfn1 mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality before implantation, complete penetrance ( J:77643 )
• homozygous embryos died between the two and four cell stage




Genotype
MGI:2669612
hm2
Allelic
Composition		 Pfn1tm1Wit/Pfn1tm1Wit
Genetic
Background		 involves: 129S4/SvJae * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pfn1tm1Wit mutation (0 available); any Pfn1 mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality before implantation, complete penetrance ( J:77643 )
• homozygous embryos die between the two and four cell stage




Genotype
MGI:2669614
hm3
Allelic
Composition		 Pfn1tm1Wit/Pfn1tm1Wit
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pfn1tm1Wit mutation (0 available); any Pfn1 mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality before implantation, complete penetrance ( J:77643 )
• homozygous embryos die between the two and four cell stage




Genotype
MGI:2669618
ht4
Allelic
Composition		 Pfn1tm1Wit/Pfn1+
Genetic
Background		 B6.129S4-Pfn1tm1Wit
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pfn1tm1Wit mutation (0 available); any Pfn1 mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
perinatal lethality, incomplete penetrance ( J:77643 )
• in some genetic backgrounds, loss of some heterozygous embryos was noted in the perinatal period; surviving mice were phenotypically identical to wild-type littermates
prenatal lethality, incomplete penetrance ( J:77643 )
• a partial loss of heterozygous embryos occurred at the two to four cell stage when the mother was heterozygous, suggesting a maternal effect due to decreased levels of profilin I in oocytes




Genotype
MGI:2669613
ht5
Allelic
Composition		 Pfn1tm1Wit/Pfn1+
Genetic
Background		 involves: 129S4/SvJae * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pfn1tm1Wit mutation (0 available); any Pfn1 mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
perinatal lethality, incomplete penetrance ( J:77643 )
• in some genetic backgrounds, loss of some heterozygous embryos was noted in the perinatal period; surviving mice were phenotypically identical to wild-type littermates
prenatal lethality, incomplete penetrance ( J:77643 )
• a partial loss of heterozygous embryos occurred at the two to four cell stage when the mother was heterozygous, suggesting a maternal effect due to decreased levels of profilin I in oocytes




Genotype
MGI:2669615
ht6
Allelic
Composition		 Pfn1tm1Wit/Pfn1+
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pfn1tm1Wit mutation (0 available); any Pfn1 mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
perinatal lethality, incomplete penetrance ( J:77643 )
• in some genetic backgrounds, loss of some heterozygous embryos was noted in the perinatal period; surviving mice were phenotypically identical to wild-type littermates
prenatal lethality, incomplete penetrance ( J:77643 )
• a partial loss of heterozygous embryos occurred at the two to four cell stage when the mother was heterozygous, suggesting a maternal effect due to decreased levels of profilin I in oocytes




Genotype
MGI:4367099
cx7
Allelic
Composition		 Ldlrtm1Her/Ldlrtm1Her
Pfn1tm1Wit/Pfn1+
Genetic
Background		 B6.129S-Ldlrtm1Her Pfn1tm1Wit
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ldlrtm1Her mutation (21 available); any Ldlr mutation (83 available)
Pfn1tm1Wit mutation (0 available); any Pfn1 mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, incomplete penetrance ( J:140294 )
• produced at a lower than expected ratio
• mice surviving to adulthood are healthy and normal regardless of diet fed

cardiovascular system
atherosclerotic lesions ( J:140294 )
• lesions are reduced by 60% in males and 75% in females after 2 months on a high cholesterol diet as compared to Ldlr deficient mice
• less area in lesions is occupied by macrophage
• macrophage recruitment to lesion sites is reduced early in lesion formation

immune system
impaired macrophage chemotaxis ( J:140294 )
• macrophage recruitment to atherosclerotic lesion sites is reduced early in lesion formation
• ess area in lesions is occupied by macrophage

cellular
impaired macrophage chemotaxis ( J:140294 )
• macrophage recruitment to atherosclerotic lesion sites is reduced early in lesion formation
• ess area in lesions is occupied by macrophage

hematopoietic system
impaired macrophage chemotaxis ( J:140294 )
• macrophage recruitment to atherosclerotic lesion sites is reduced early in lesion formation
• ess area in lesions is occupied by macrophage




Genotype
MGI:3718223
cx8
Allelic
Composition		 Enahtm1Fbg/Enahtm1Fbg
Pfn1tm1Wit/Pfn1+
Genetic
Background		 involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Enahtm1Fbg mutation (0 available); any Enah mutation (208 available)
Pfn1tm1Wit mutation (0 available); any Pfn1 mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
perinatal lethality, complete penetrance ( J:53259 )
• no viable animals of expected genotype from double heterozygous cross
• present in expected Mendelian frequencies at E9.5 and E16

embryo
incomplete rostral neuropore closure ( J:53259 )
• cephalic neural tube failed to close in half of embryo

growth/size/body
decreased embryo size ( J:53259 )
• at E9.5

nervous system
incomplete rostral neuropore closure ( J:53259 )
• cephalic neural tube failed to close in half of embryo
anencephaly ( J:53259 )
• at E16.5 in 1 of 9 embryos
exencephaly ( J:53259 )
• at E16.5 in 4 of 9 embryos




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory