Analysis Tools
mortality/aging
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• homozygous embryos died between the two and four cell stage
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Allele Symbol Allele Name Allele ID |
Pfn1tm1Wit targeted mutation 1, Walter Witke MGI:2183296 |
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| Summary |
8 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• homozygous embryos died between the two and four cell stage
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• homozygous embryos die between the two and four cell stage
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• homozygous embryos die between the two and four cell stage
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• in some genetic backgrounds, loss of some heterozygous embryos was noted in the perinatal period; surviving mice were phenotypically identical to wild-type littermates
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• a partial loss of heterozygous embryos occurred at the two to four cell stage when the mother was heterozygous, suggesting a maternal effect due to decreased levels of profilin I in oocytes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• in some genetic backgrounds, loss of some heterozygous embryos was noted in the perinatal period; surviving mice were phenotypically identical to wild-type littermates
|
|
• a partial loss of heterozygous embryos occurred at the two to four cell stage when the mother was heterozygous, suggesting a maternal effect due to decreased levels of profilin I in oocytes
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• in some genetic backgrounds, loss of some heterozygous embryos was noted in the perinatal period; surviving mice were phenotypically identical to wild-type littermates
|
|
• a partial loss of heterozygous embryos occurred at the two to four cell stage when the mother was heterozygous, suggesting a maternal effect due to decreased levels of profilin I in oocytes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• produced at a lower than expected ratio
• mice surviving to adulthood are healthy and normal regardless of diet fed
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• lesions are reduced by 60% in males and 75% in females after 2 months on a high cholesterol diet as compared to Ldlr deficient mice
• less area in lesions is occupied by macrophage
• macrophage recruitment to lesion sites is reduced early in lesion formation
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• macrophage recruitment to atherosclerotic lesion sites is reduced early in lesion formation
• ess area in lesions is occupied by macrophage
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• macrophage recruitment to atherosclerotic lesion sites is reduced early in lesion formation
• ess area in lesions is occupied by macrophage
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• macrophage recruitment to atherosclerotic lesion sites is reduced early in lesion formation
• ess area in lesions is occupied by macrophage
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• no viable animals of expected genotype from double heterozygous cross
• present in expected Mendelian frequencies at E9.5 and E16
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• at E9.5
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• cephalic neural tube failed to close in half of embryo
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• at E9.5
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• cephalic neural tube failed to close in half of embryo
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• at E16.5 in 1 of 9 embryos
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• at E16.5 in 4 of 9 embryos
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 07/05/2024 MGI 6.24 |
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