All Phenotypes Apob<tm1.1Zc> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Apob^tm1.1Zc
targeted mutation 1.1, Zhouji Chen
MGI:2183298

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Apob^tm1.1Zc/Apob^tm1.1Zc	involves: 129X1/SvJ * C57BL/6	MGI:2663449
ht2	Apob^tm1.1Zc/Apob⁺	involves: 129X1/SvJ * C57BL/6	MGI:2663451
ht3	Apob^tm1Zc/Apob^tm1.1Zc	involves: 129/Sv * C57BL/6	MGI:2663775

Allelic Composition	Apob^tm1.1Zc/Apob^tm1.1Zc
Genetic Background	involves: 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apob^tm1.1Zc mutation (3 available); any Apob mutation (224 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, incomplete penetrance ( J:65191 )

• fewer than expected numbers of offspring born from heterozygous matings

homeostasis/metabolism

decreased circulating HDL cholesterol level ( J:65191 )

decreased circulating LDL cholesterol level ( J:65191 )

decreased circulating VLDL cholesterol level ( J:65191 )

decreased circulating triglyceride level ( J:65191 )

liver/biliary system

hepatic steatosis ( J:65191 )

Allelic Composition	Apob^tm1.1Zc/Apob⁺
Genetic Background	involves: 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apob^tm1.1Zc mutation (3 available); any Apob mutation (224 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased circulating LDL cholesterol level ( J:65191 )

decreased circulating VLDL cholesterol level ( J:65191 )

liver/biliary system

hepatic steatosis ( J:65191 )

Allelic Composition	Apob^tm1Zc/Apob^tm1.1Zc
Genetic Background	involves: 129/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apob^tm1.1Zc mutation (3 available); any Apob mutation (224 available)
Apob^tm1Zc mutation (0 available); any Apob mutation (224 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased circulating cholesterol level ( J:76047 )

decreased circulating HDL cholesterol level ( J:76047 )

decreased circulating LDL cholesterol level ( J:76047 )

decreased circulating VLDL cholesterol level ( J:76047 )

decreased circulating triglyceride level ( J:76047 )

liver/biliary system

hepatic steatosis ( J:76047 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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