Phenotypes associated with this allele

• Allele Symbol: Tiam1^tm1Jgc
• Allele Name: targeted mutation 1, John G Collard
• Allele ID: MGI:2183309
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tiam1^tm1Jgc/Tiam1^tm1Jgc	involves: 129P2/OlaHsd * FVB	MGI:3033312
ht2	Tiam1^tm1Jgc/Tiam1^+	involves: 129P2/OlaHsd * FVB	MGI:3033313

Genotype
MGI:3033312

hm1

• Allelic Composition: Tiam1^tm1Jgc/Tiam1^tm1Jgc
• Genetic Background: involves: 129P2/OlaHsd * FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

decreased incidence of tumors by chemical induction ( J:77148 )

• fewer skin tumors developed after DMBA initiation followed by TPA promotion compared to wild-type controls

• few tumors that did result grew much more slowly than similarly produced tumors in wild-type controls

• fewer skin tumors developed after DMBA treatment alone

• few tumors that did result grew at same rate as similarly produced tumors in wild-type controls

increased malignant tumor incidence ( J:77148 )

• despite fewer tumors, those that developed had proportionally increased progression to malignancy

• were severely dysplastic papillomas, showing carcinoma in situ and/or focal invasion or were squamous cell carcinoma

increased squamous cell carcinoma incidence ( J:77148 )

• tumors that did develop progressed to malignancy, showing carcinoma in situ and/or focal invasion or were squamous cell carcinoma

cellular

abnormal apoptosis ( J:77148 )

• increased apoptosis at the basal layer of the epidermis during initiation with DMBA

decreased cell proliferation ( J:77148 )

• at the basal layer of hyperplastic epidermis during tumor promotion

homeostasis/metabolism

decreased incidence of tumors by chemical induction ( J:77148 )

• fewer skin tumors developed after DMBA initiation followed by TPA promotion compared to wild-type controls

• few tumors that did result grew much more slowly than similarly produced tumors in wild-type controls

• fewer skin tumors developed after DMBA treatment alone

• few tumors that did result grew at same rate as similarly produced tumors in wild-type controls

Genotype
MGI:3033313

ht2

• Allelic Composition: Tiam1^tm1Jgc/Tiam1⁺
• Genetic Background: involves: 129P2/OlaHsd * FVB

neoplasm

decreased incidence of tumors by chemical induction ( J:77148 )

• fewer skin tumors developed after DMBA initiation followed by TPA promotion compared to wild-type controls, but more than homozygous mutant mice

• few tumors that did result grew more slowly than similarly produced tumors in wild-type controls, but more rapidly than homozygous mutant mice

homeostasis/metabolism

decreased incidence of tumors by chemical induction ( J:77148 )

• fewer skin tumors developed after DMBA initiation followed by TPA promotion compared to wild-type controls, but more than homozygous mutant mice

• few tumors that did result grew more slowly than similarly produced tumors in wild-type controls, but more rapidly than homozygous mutant mice