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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cebpatm1.1(Cebpb)Ylee
targeted mutation 1.1, Ying-Hue Lee
MGI:2183333
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cebpatm1.1(Cebpb)Ylee/Cebpatm1.1(Cebpb)Ylee involves: 129X1/SvJ * C57BL/6 * FVB/N MGI:3809478
ht2
 		Cebpatm1.1(Cebpb)Ylee/Cebpatm1.1Gonz involves: 129X1/SvJ * C57BL/6 * FVB/N MGI:3809479


Genotype
MGI:3809478
hm1
Allelic
Composition		 Cebpatm1.1(Cebpb)Ylee/Cebpatm1.1(Cebpb)Ylee
Genetic
Background		 involves: 129X1/SvJ * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cebpatm1.1(Cebpb)Ylee mutation (0 available); any Cebpa mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
adipose tissue
abnormal brown adipose tissue morphology ( J:77646 )
• brown adipose tissue is more vacuolated than in wild-type mice
abnormal fat cell morphology ( J:77646 )
• adipocytes are reduced in size and exhibit reduced lipid accumulation compared to in wild-type mice
abnormal white adipose tissue morphology ( J:77646 )
• white adipose tissue is reduced and yellow compared to in wild-type mice

homeostasis/metabolism
homeostasis/metabolism phenotype ( J:77646 )
N
• unlike in Cebpa null mice, normal serum glucose and lipid levels

behavior/neurological
increased food intake ( J:77646 )
• mice consume 9% more food than wild-type mice

hematopoietic system
abnormal hematopoietic system physiology ( J:77646 )
• mice exhibit decreased hemolytic activity compared to wild-type mice

growth/size/body
growth/size/body region phenotype ( J:77646 )
N
• unlike in Cebpa null mice, growth is normal

immune system
immune system phenotype ( J:77646 )
N
• unlike in Cebpa null mice, acute phase response to LPS is normal

reproductive system
reproductive system phenotype ( J:77646 )
N
• mice are fertile




Genotype
MGI:3809479
ht2
Allelic
Composition		 Cebpatm1.1(Cebpb)Ylee/Cebpatm1.1Gonz
Genetic
Background		 involves: 129X1/SvJ * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cebpatm1.1(Cebpb)Ylee mutation (0 available); any Cebpa mutation (19 available)
Cebpatm1.1Gonz mutation (0 available); any Cebpa mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
adipose tissue
abnormal white adipose tissue morphology ( J:77646 )
• white adipose tissue is reduced and yellow compared to in wild-type mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory