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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tbptm1.1Ees
targeted mutation 1.1, Edward E Schmidt
MGI:2183359
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tbptm1.1Ees/Tbptm1.1Ees B6.129X1(Cg)-Tbptm1.1Ees MGI:3720048
ht2
 		Tbptm1.1Ees/Tbp+ B6.129X1(Cg)-Tbptm1.1Ees MGI:3720050
cx3
 		B2mtm1Unc/B2mtm1Unc
Tbptm1.1Ees/Tbptm1.1Ees 		involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 MGI:3720051


Genotype
MGI:3720048
hm1
Allelic
Composition		 Tbptm1.1Ees/Tbptm1.1Ees
Genetic
Background		 B6.129X1(Cg)-Tbptm1.1Ees
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tbptm1.1Ees mutation (0 available); any Tbp mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, incomplete penetrance ( J:77714 )
• 67% of surviving mice die prior to weaning
embryonic lethality during organogenesis, incomplete penetrance ( J:77714 )
• most recovered embryos are dying or resorbed between E10.5 and E12.5 91% of embryos are lost between E10.5 and E12.5
• however, survival can be increased by using Rag null mothers

embryo
placenta hemorrhage ( J:77714 )
• hemorrhages are evident in the placenta

immune system
hemophagocytosis ( J:77714 )
• hemophagocytosis is evident in the placenta

hematopoietic system
hemophagocytosis ( J:77714 )
• hemophagocytosis is evident in the placenta

homeostasis/metabolism
abnormal blood coagulation ( J:77714 )
• ~25% of placentas have regions showing mixing of maternal and embryonic blood, and clots of maternal blood are abundant

cardiovascular system
placenta hemorrhage ( J:77714 )
• hemorrhages are evident in the placenta

growth/size/body
fetal growth retardation ( J:77714 )
• prior to death pups exhibit varying degrees of growth retardation




Genotype
MGI:3720050
ht2
Allelic
Composition		 Tbptm1.1Ees/Tbp+
Genetic
Background		 B6.129X1(Cg)-Tbptm1.1Ees
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tbptm1.1Ees mutation (0 available); any Tbp mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, incomplete penetrance ( J:77714 )
• 22% of embryos die between E10.5 and E12.5

growth/size/body
fetal growth retardation ( J:77714 )
• prior to death pups exhibit varying degrees of growth retardation




Genotype
MGI:3720051
cx3
Allelic
Composition		 B2mtm1Unc/B2mtm1Unc
Tbptm1.1Ees/Tbptm1.1Ees
Genetic
Background		 involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
B2mtm1Unc mutation (38 available); any B2m mutation (122 available)
Tbptm1.1Ees mutation (0 available); any Tbp mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, incomplete penetrance ( J:77714 )
• 6-fold more embryos survive than in Tbptm1.1Ees homozygotes




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory