Phenotypes associated with this allele

• Allele Symbol: Tpst1^tm1Klm
• Allele Name: targeted mutation 1, Kevin L Moore
• Allele ID: MGI:2183366
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tpst1^tm1Klm/Tpst1^tm1Klm	129S-Tpst1^tm1Klm	MGI:2655588

Genotype
MGI:2655588

hm1

• Allelic Composition: Tpst1^tm1Klm/Tpst1^tm1Klm
• Genetic Background: 129S-Tpst1^tm1Klm

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body weight ( J:77674 )

• mean body weight is normal through weaning at 3 weeks of age

• by 5-6 weeks of age weights are approximately 5% less than controls

• homozygotes are otherwise healthy through 12 months of age

reproductive system

reduced female fertility ( J:77674 )

♀ • post implantation fetal loss occurs between E8.5 and E15.5 and is 3X higher than controls

decreased litter size ( J:77674 )

♀ • homozygous females produce smaller sized litters regardless of the paternal genotype

♀ • litter size reduction independent of fetal genotype

behavior/neurological

abnormal maternal nurturing ( J:77674 )

♀ • increased incidence of perinatal mortality

♀ • 28% of pups born die within 48 hours of birth